Prognostic analysis of 182 newly diagnosed multiple myeloma patients with high risk cytogenetic abnormalities
10.3760/cma.j.issn.0253-2727.2019.08.004
- VernacularTitle: 182例初诊伴高危细胞遗传学异常多发性骨髓瘤患者的预后分析
- Author:
Xuelian LIU
1
;
Jing BAI
;
Hongqiong FAN
;
Yanping YANG
;
Tingting YUE
;
Ye ZHANG
;
Peiyu YANG
;
Sujun GAO
;
Wei LI
;
Fengyan JIN
Author Information
1. Department of Hematology, Cancer Center, the First Affiliated Hospital of Jilin University, Changchun 130021, China
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Cytogenetic abnormality;
High risk;
Prognosis
- From:
Chinese Journal of Hematology
2019;40(8):644-649
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the clinical characteristics and prognosis of high risk cytogenetic abnormalities (HRCA) and various combinations of cytogenetic abnormality in patients with newly-diagnosed multiple myeloma (NDMM) .
Methods:This retrospective study collected 182 NDMM patients in the First Affiliated Hospital of Jilin University between Nov. 2009 and May 2018. HRCA included 1q+, del (17p) , t (4;14) , and t (14;16) detected by FISH, and non-HRCA included del (13q) , t (11;14) detected by FISH. The clinical characteristics among three groups, including cases who carrying a single HRCA, 1 HRCA in combination with non-HRCA and cases carrying two or more HRCAs (double/triple-hit) were observed. Kaplan-Meier curve was used to analyze both progression-free survival (PFS) and overall survival (OS) for the three groups.
Results:The survivals of patients with 1 HRCA in combination with non-HRCA were similar to those with two or more HRCAs (double/triple-hit) , the median PFS (mPFS) was 19.1 m vs 12.1 m (P=0.248) and median OS (mOS) was 29.6 m vs 29.3 m (P=0.774) . Furthermore, the prognosis of these two groups were both inferior to patients with a single HRCA, respectively. (mPFS: 32.2 m, P=0.040, P=0.001; mOS: 42.3 m, P=0.021, P=0.041) . Strikingly, both the mPFS and the mOS of patients with 1 HRCA in combination with non-HRCA (regardless of high risk or not) were significantly shorter than that of cases with a single HRCA (mPFS: 15.1 m vs 32.2 m, HR=2.126, 95%CI 1.176-3.843, P=0.005; mOS: 29.3 m vs 42.3 m, HR=1.442, 95%CI 0.705-2.950, P=0.011) .
Conclusion:It is of prognostic significance value for detecting double/triple-hit based on FISH cytogenetics in NDMM.
