The relationship between inflammatory markers and the risk of lung cancer: a prospective cohort study

Gang Wang; Luopei Wei; Ni LI; Weiguo XU; Kai SU; Fang LI; Fengwei Tan; Zhangyan Lyu; Xiaoshuang Feng; Xin LI; Hongda Chen; Yuheng Chen; Lanwei Guo; Hong Cui; Pengfei Jiao; Hexin Liu; Jiansong Ren; Shouling WU; Jufang Shi; Min Dai; Jie HE

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The relationship between inflammatory markers and the risk of lung cancer: a prospective cohort study

VernacularTitle: 炎性因子水平与肺癌发病风险的前瞻性队列研究
Author: Gang WANG ¹ ; Luopei WEI ² ; Ni LI ² ; Weiguo XU ³ ; Kai SU ⁴ ; Fang LI ⁴ ; Fengwei TAN ⁴ ; Zhangyan LYU ² ; Xiaoshuang FENG ² ; Xin LI ² ; Hongda CHEN ² ; Yuheng CHEN ² ; Lanwei GUO ² ; Hong CUI ² ; Pengfei JIAO ¹ ; Hexin LIU ¹ ; Jiansong REN ² ; Shouling WU ⁵ ; Jufang SHI ² ; Min DAI ² ; Jie HE ⁴
Author Information

1. Department of Oncology, Kailuan General Hospital, Tangshan 063000, China
2. Office of Cancer Screeening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
3. Department of Surgical Oncology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China
4. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
5. Department of Cardiology, Kailuan General Hospital, Tangshan 063000, China
Publication Type:Journal Article
Keywords: Lung neoplasms; C-reactive protein; Neutrophil; Cohort study
From: Chinese Journal of Oncology 2019;41(8):633-637
CountryChina
Language:Chinese
Abstract: Objective:To investigate whether elevated levels of C-reactive protein (CRP) and neutrophil (NE) in the blood is associated with an increased risk of lung cancer incidence.
Methods:From 2006 to 2007, all employees and retirees from Kailuan (Group) Limited liability Corporation were included in this Kailuan Cohort study. The last follow-up date was December 2015. Data on new cases of lung cancer were collected, and multivariable Cox proportional hazards regression models were used to the relationship between baseline CRP and NE at baseline and risk of lung cancer.
Results:A total of 92 735 participants were enrolled in this study. During the follow-up, 850 new cases of lung cancer were identified. All subjects were divided into four groups according to the combination level of CRP and NE at baseline: CRP≤3 mg/L and NE≤4×10⁹/L(Group A), CRP≤3 mg/L and NE>4×10⁹/L(Group B), CRP>3 mg/L and NE≤4×10⁹/L(Group C), CRP>3 mg/L and NE>4×10⁹/L(Group D). The cumulative incidence of lung cancer were 950/100 000, 1 030/100 000, 1 081/100 000 and 1 596/100 000 in these four groups, respectively (P<0.001). Multivariate Cox proportional risk model showed that participants from Group D had an significantly increased 72% risks of lung cancer when compared to Group A (95% CI: 1.40~2.12, P<0.001). Stratified analyses gender showed that males in Group D had higher risk of lung cancer when compared with participants in Group A (HR=1.73, 95% CI: 1.40~2.15, P<0.001).
Conclusion:Elevated levels of CRP and NE might increase the risk of lung cancer.