Analysis of clinicopathological features of patients with simple breast cancer and breast cancer with thyroid cancer
10.3760/cma.j.issn.0253-3766.2019.08.012
- VernacularTitle: 单纯乳腺癌与乳腺癌合并甲状腺癌患者临床病理特征分析
- Author:
Haibo YANG
1
;
Jinnan GAO
1
;
Wanzhi SONG
2
Author Information
1. Department of Breast Surgery, Shanxi Dayi Hospital, Taiyuan 030032, China
2. Multi-disciplinary Team Center, First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Clinical Trail
- Keywords:
Breast neoplasms;
Thyroid neoplasms;
Clinicopathological features
- From:
Chinese Journal of Oncology
2019;41(8):624-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between breast cancer and thyroid cancer.
Methods:A cohort of 747 female patients with stage Ⅰ-Ⅲ invasive breast cancer were enrolled in this retrospective study. The differences of clinical and pathological data were compared between the simple breast cancer group (723 cases) and the breast cancer with thyroid cancer group (24 cases), to analyze the relevant factors of second primary thyroid cancer in patients with breast cancer.
Results:There were significant differences in the menstrual status and estrogen receptor (ER) status between the group of patients with breast cancer only and breast cancer patients with secondary primary thyroid cancer (P<0.05). Breast cancer patients with secondary primary thyroid cancer were more likely to be premenopausal (75%) and ER-positive (83.3%). Multivariate logistic regression analysis showed that the patient′s menstrual status (compared with premenopausal patients, peri-menopausal odds ratio=0.53, 95% CI 0.07-4.25; post-menopausal odds ration=0.23, 95%CI 0.08-0.65) and body mass index (BMI, odds ratio=1.14, 95%CI 1.02-1.28) were independent risk factors for secondary primary thyroid cancer in patients with breast cancer.
Conclusion:Thyroid cancer is associated with breast cancer, and is more likely to occur in obesity patients and premenopausal patients.
