Effect of preoperative Nutritional Risk Screening-2002 combined with hematologic inflammatory markers on prognosis of thoracic esophageal squamous cell carcinoma
10.3760/cma.j.issn.0253-3766.2019.08.009
- VernacularTitle: 术前营养风险筛查2002联合血液炎性指标对胸段食管鳞癌预后的影响
- Author:
Xinwei GUO
1
;
Li ZHU
1
;
Hongxun YE
1
;
Shaobing ZHOU
1
;
Yangchen LIU
1
;
Juying ZHOU
2
;
Shengjun JI
3
Author Information
1. Department of Radiation Oncology, Affiliated Taixing People′s Hospital of Yangzhou University, Taixing 225400, China
2. Department of Radiation Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
3. Department of Radiotherapy and Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, China
- Publication Type:Clinical Trail
- Keywords:
Esophageal neoplasms;
Carcinoma, squamous cell;
Radical surgery;
Nutritional risk screening;
Inflammatory markers;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(8):604-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate preoperative nutritional status and inflammatory status by Nutritional Risk Screening-2002 (NRS-2002) and hematologic inflammatory markers in patients with thoracic esophageal squamous cell carcinoma (ESCC), and to explore their effects on long-term survival prognosis.
Methods:A total of 113 patients with thoracic ESCC treated by radical resection were grouped for further analysis according to preoperative NRS-2002 score, systemic inflammation score (SIS) and the combination of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio (CNP) score. The progression free survival (PFS) and overall survival (OS) between groups were compared. Multivariate Cox regression analysis was used to determine the independent prognostic factors of patients with thoracic esophageal squamous cell carcinoma, and the interaction analysis of statistically significant factors was carried out.
Results:The median PFS was 21 months for all the patients. The 1-year, 3-year and 5-year PFS rates were 69.0%, 25.7% and 23.1%, respectively. Correspondingly, the median OS was 36 months, and the 1-year, 3-year and 5-year OS rates were 95.6%, 46.2% and 29.2%, respectively. Cox univariate analysis showed that T stage, N stage, TNM stage, SIS, CNP score and NRS-2002 score were significantly associated with PFS and OS (all P<0.05), and sex was associated with PFS (P=0.032) in patients with thoracic ESCC. Furthermore, cox multivariate analysis showed that TNM stage (HR=1.570, P=0.039), NRS-2002 score (HR=2.706, P<0.001) and CNP score (HR=1.463, P=0.011) were independent prognosis factors of PFS in patients with thoracic ESCC. In cox model interaction analysis, there was a positive interaction between NRS-2002 score and CNP score (RR=2.789, P<0.001).
Conclusion:Preoperative NRS-2002 score combined with CNP score are risk factors for prognosis of patients with thoracic ESCC, which can be used as prognostic indicators.
