Association study of genetic variations in SLCO1B3 gene with prognosis in breast cancer patients treated with neoadjuvant chemotherapy of TA regimen
10.3760/cma.j.issn.0253-3766.2019.08.006
- VernacularTitle: 有机阴离子转运多肽1B3基因遗传变异与TA方案新辅助化疗乳腺癌患者预后的关联研究
- Author:
Zhongli DU
1
;
Chengshan XU
1
;
Zhimin BIAN
2
;
Mingting PENG
1
;
Chenbin LI
1
;
Ting FENG
3
;
Xiaozhou XU
4
;
Haijing LIU
5
;
Bailin ZHANG
4
Author Information
1. National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
2. Comprehensive Oncology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
3. Department of Pathology, Beijing Hepingli Hospital, Beijing 100013, China
4. Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
5. Department of Pharmacy, Kailuan General Hospital, Tangshan 063000, China
- Publication Type:Clinical Trail
- Keywords:
Breast neoplasms;
SLCO1B3 gene;
Polymorphism, single nucleotide;
Neoadjuvant chemotherapy;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(8):587-593
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association of single nucleotide polymorphisms (SNPs) in SLCO1B3 gene with prognosis of breast cancer (BC) patients treated with neoadjuvant chemotherapy of TA regimen (taxane and antharcycline drugs).
Methods:439 female BC patients were recruited and treated with neoadjuvant chemotherapy of TA regimen. A blood sample (2 ml) of peripheral blood was collected from each patient before chemotherapy. Tagging SNPs (tag-SNPs) were selected. We investigated the association of tag-SNPs with prognosis, by Sequenom Mass ARRAY system platform, characterizing tag-SNPs. The hazard ratio (HR) and 95% confidence interval (CI) for progression or death were calculated by multivariable-adjusted Cox regression model.
Results:Seven tag-SNPs (rs11045689, rs200104106, rs3764006, rs3834935, rs4149117, rs7305323 and rs73241801) were selected for study. Compared with individuals carrying the rs11045689 GG genotype, individuals carrying rs11045689 AA genotype performed worse PFS and OS, with the HR (95% CI) for progression being 1.39 (1.11~1.75) and the HR (95% CI) for death being 1.38 (1.04~1.83). Compared with individuals carrying the rs73241801 CC genotype, individuals carrying rs73241801 TT genotype performed better OS (P=0.041), with the HR (95% CI) for death being 0.65 (0.44~0.94). The number of risk allele was significantly associated with PFS (P=0.012) and OS (P=0.017) of BC patients by accumulation analysis. Compared with individuals carrying one or less than one risk allele, individuals carrying four risk alleles performed worse PFS and OS, with the HR (95% CI) for progression being 1.37 (1.09~1.72) and the HR (95% CI) for death being 1.36 (1.02~1.81).
Conclusion:The variations of rs11045689 and rs73241801 in SLCO1B3 gene were significantly associated with prognosis of BC patients treated with neoadjuvant chemotherapy of TA regimen, which might serve as biomarkers for predicting prognosis of BC patients treated with neoadjuvant chemotherapy.
