Effect of vascular changes on prognosis after induced chemotherapy for advanced hypopharyngeal carcinoma
10.3760/cma.j.issn.1673-0860.2019.08.006
- VernacularTitle: 晚期下咽癌诱导化疗后血管变化对预后的影响
- Author:
Wei GUO
1
;
Gaofei YIN
1
;
Junwei HUANG
1
;
Zheng YANG
1
;
Hongfei LIU
1
;
Yang ZHANG
1
;
Hongbo XU
1
;
Zeyang LIU
1
;
Zhigang HUANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Captical Medical University, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
Hypopharyngeal carcinoma;
Narrow band imaging;
Induced chemotherapy;
Prognosis;
Survival analysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(8):591-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of two groups(vascular classification declines or not in narrow band imaging (NBI) of patients with advanced hypopharyngeal carcinoma after induced chemotherapy, to follow-up and compare the survival differences between the two groups, and to explore the effect of vascular changes on clinical prognosis after induced chemotherapy in patients with advanced hypopharyngeal carcinoma.
Methods:Clinical data of 56 patients with advanced hypopharyngeal carcinoma from August 2014 to September 2016 in Beijing Tongren Hospital, Capital Medical University were collected. The patients were divided into two groups according to NBI vascular classification declines or not after induced chemotherapy. The survival of patients and the impact of different factors on the prognosis were retrospectively analyzed. SPSS 24.0 statistical software was used for analysis. Frequency data were compared between the two groups using χ2 test. Kaplan-Meier method and Cox regression analysis were employed for survival analysis and Log-Rank test was used for inter-group comparison, P<0.05 was statistically significant.
Results:There was significant difference in overall survival rate(OS) between two groups of patients with advanced hypopharyngeal carcinoma after induced chemotherapy (P<0.05). Multivariate analysis showed that NBI vascular classification changes after induced chemotherapy was the impact factor for prognosis of advanced hypopharyngeal carcinoma after induced chemotherapy.
Conclusion:In addition to recurrence and metastasis, NBI vascular classification changes is the important impact factor for prognosis of advanced hypopharyngeal carcinoma after induced chemotherapy. Patients with NBI vascular classification declines have significant survival benefit. The patients with advanced hypopharyngeal carcinoma should be checked with NBI examination before and after induced chemotherapy. NBI should be included in the routine screening indicators for prognosis of advanced hypopharyngeal carcinoma.
