Epidemiological and pathogenic features of a bacillary dysentery outbreak in a boarding school caused by Shigella sonneri
10.3760/cma.j.issn.0254-6450.2019.08.021
- VernacularTitle: 一起由宋内志贺菌引起的寄宿学校细菌性痢疾暴发病原学和流行病学分析
- Author:
Zhaoqian MENG
1
;
Ran DUAN
2
;
Ge BU
1
;
Guoxia GUO
1
;
Liangzi GUO
1
;
Yunkai HU
1
Author Information
1. Fuyang Municipal Center for Disease Control and Prevention of Anhui Province, Fuyang 236000, China
2. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
Shigella sonnei;
Drug susceptibility test;
Virulence genes
- From:
Chinese Journal of Epidemiology
2019;40(8):988-991
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the etiologic and epidemiologic features of an infectious diarrhea outbreak in a boarding school in Fuyang city, Anhui province.
Methods:Traceability hypothesis of this study was tested according to the epidemiological characteristics of the cases. Feces, anal swabs, water samples and food residues related to the patients and chefs were collected for pathogen isolation and detection. Biochemical identification, virulence gene detection, drug susceptibility test, PFGE and multilocus sequence typing were performed.
Results:The incidence rate (3.41%) of different dormitory buildings within the water supply area by shallow wells was higher than that (0.98%) of the deep wells, with statistical significance (χ2=17.215, P<0.001). Sixteen strains belonged to the Shigella Sonneri family were isolated from the patient’s samples, and all carrying the ipaH gene. Seven strains belonged to sen and ial genes. Set1 gene that did not appear in all the 16 strains were highly resistant to ampicillin, tetracycline, compound xinnomine, cefazoline, cefotaxime, gentamicin, naphthidinic acid and streptomycin, including 9 strains to doxycycline. The pulse field pattern of the 16 strains of Shigella sonneri appeared the same, with the ST type as ST152.
Conclusion:When combined data from the etiological and epidemiological investigation, it was confirmed that Shigella sonneri was the pathogen of this outbreak, and water from the shallow wells might be responsible for the source of infection.
