Study on HIV-1 genetics and drug resistance among HIV infected individuals who initiated antiretroviral therapy in Dehong Dai and Jingpo autonomous prefecture, 2017
10.3760/cma.j.issn.0254-6450.2019.08.020
- VernacularTitle: 德宏傣族景颇族自治州2017年HIV-1感染者抗病毒治疗前耐药和病毒基因亚型研究
- Author:
Huichao CHEN
1
;
Jibao WANG
2
;
Hui XING
3
;
Yanling MA
1
;
Xing DUAN
2
;
Jie DAI
1
;
Xiaomei JIN
1
;
Shitang YAO
2
;
Song DUAN
2
;
Min CHEN
1
Author Information
1. Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China
2. Department of AIDS/STD Control and Prevention, Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention, Mangshi 678400, China
3. Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
HIV;
Genotype;
Drug resistance;
Antiretroviral therapy
- From:
Chinese Journal of Epidemiology
2019;40(8):982-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the distribution of HIV-1 genotypes and the status of drug resistance among people living with HIV who had prepared to initiate antiretroviral therapy (ART) in Dehong Dai and Jingpo autonomous prefecture (Dehong).
Methods:A total of 170 adults with HIV were recruited in Dehong from January to June 2017, before initiating ART. HIV-1 pol genes were amplified and used to analyze the HIV-1 genotypes and drug resistance.
Results:A total of 147 samples were successfully sequenced. Based on the phylogenetic analysis, 12 HIV-1 genotypes were found among the subjects, including three predominant genotypes such as subtype C (29.9%, 44/147), unique recombinant forms (URFs) (27.2%, 40/147) and CRF01_AE (19.7%, 29/147). Circulating recombinant forms (CRFs) which were newly identified in this area in recent years were also found among these subjects, including CRF62_BC, CRF64_BC, CRF86_BC and CRF96_cpx. The distribution of HIV-1 genotypes between heterosexual transmission or intravenous drug use, showed statistical difference. Surveillance drug resistance mutations (SDRMs) were found among 8.8% (13/147) of the subjects. Proportion of drug resistant strains among injecting drug users (25.0%, 8/32) was higher than that among those heterosexual transmitted individuals (4.6%, 5/109, χ2=10.166, P=0.002).
Conclusions:Among people living with HIV-1 who had prepared to initiate ART, their HIV-1 genetics were highly complicated, with moderate prevalence rate of HIV-1 drug-resistant strains.
