Mechanism of promoted neovascularization by SVF after fat grafting

VernacularTitle: 基质血管片段促进脂肪移植后再血管化机制的研究进展
Author: Zhengcai WANG ¹ ; Jingjing MA ; Zichun GU ; Wenjia SUN ; Li CHEN ; Hua LI
Author Information

1. Department of Plastic and Reconstructive Surgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, China
Publication Type:Review
Keywords: Fat transplantation; Stromal vascular fraction; Adipose-derived stem cells; Revascularization; Mechanism
From: Chinese Journal of Plastic Surgery 2019;35(8):814-818
CountryChina
Language:Chinese
Abstract: Stromal vascular fraction(SVF)are the remaining cells after removing mature fat cells in the adipose tissue. Containing a certain amount of adipose derived stem cells(ADSCs), SVF also includes many other cells, which may have the potential of promoting angiogenesis. In this review, the role of SVF in angiogenesis after fat transplantation was summarized by intensive reading relative literature in recent years. The result is that angiogenesis and fat graft revascularization are regulated by various factors: SVF promotes secretion of a diverse array of cytokines and growth which are capable of stabilizing endothelium vascular network. ADSCs have the potential of differentiating into smooth muscle cells and endothelial cells which can coroperate to form new blood vessels.