Rapid determination of 21 elements in urine by inductively coupled plasma mass spectrometry
10.3760/cma.j.issn.1001-9391.2019.08.017
- VernacularTitle: 快速测定尿液中21种元素含量的电感耦合等离子体质谱法
- Author:
Fangda PENG
1
;
Chunguang DING
1
;
Huanqiang WANG
2
Author Information
1. National Center of Occupational Safety and Health, beijing 102308, China
2. National Institute of Occupational Health and Poison Control, beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Inductively coupled plasma mass spectrometry (ICP-MS);
Urine;
rapid determination;
Element
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(8):622-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a rapid detection method for 21 elements in urine with inductively coupled plasma mass spectrometry (ICP-MS) .
Methods:The urine samples were directly diluted 20 times by 1% HNO3, and detected by ICP-MS, Indium, Yttrium, and Lutecium were used as on-line internal standard. Fe was analyzed by Dynamic Reaction Cell (DRC) mode, As, Cr, V and Zn were analyzed by collision cell technology (CCT) mode, and Be, Mn, Ni, Cd, Sn, Bi, Pb, Re, Sb, W, Li, Cu, Se, Sr, Mo were analyzed by standard mode. Dynamic band-pass tuning (DBT) was used to eliminate interference for Fe.
Results:All the elements have good linearity in their determination range, with the correlation coefficient r>0.999 5. The limits of detection of the 21 elements were in the range of 0.017-11.14 μg/L. The inter-precision (relative standard deviation, RSD) was less than 9.96%, and the intra-precision was less than 13.90% (except As RSD<18.91%) . The spike recovery of all elements fell within 81.1%-116.4%.
Conclusion:The method was proved to be simple, fast, and accurate, and met the needs of testing requirements of large amounts of specimens.
