Elemental and isotopic determination of lead in whole blood by ISIS-ICP-MS
10.3760/cma.j.issn.1001-9391.2019.08.016
- VernacularTitle: 同时测定血铅浓度和铅同位素比值带不连续进样方式的电感耦合等离子体质谱法
- Author:
Jianpei YUN
1
;
Aihua ZHANG
2
;
Fen LIU
1
;
Tiandi LI
1
;
Yiran LIN
1
;
Qiaoyu PAN
2
Author Information
1. Shenzhen Prevention and Treatment center for Occupational Diseases, Shenzhen 518000, China
2. Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510000, China
- Publication Type:Journal Article
- Keywords:
Blood;
Lead;
Inductively coupled plasmamass specptrometry;
Isotope ratios
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(8):619-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for determination of lead and istope ratios in the blood by ISIS-ICP-MS.
Methods:After wet digestion, the blood sample was on-line addition of thallium as internal standard and analyzed by ISIS-ICP-MS.
Results:The limit of detection was 0.03 μg/L and the lower limit of quantification was 0.08 μg/L. The detection concentration was 0.45 μg/L and the minimum quantitative concentration was 1.49 μg/L. The relative standard deviations (RSD) were 0.3%~1.7%. The recovery was between 91.0% and 103.4%. The precision of the major lead isotope ratios was better than 0.3%. The calibrated isotope ratios of the standard liquid are close to the certificate.
Conclusion:The method has a low detection limit, good precision and high accuracy, it is feasible for determination of lead concentration and isotope ratios in the bloune.
