The effects of long-term exposure to silica dust on serum CC16 and KL-6 levels
10.3760/cma.j.issn.1001-9391.2019.08.002
- VernacularTitle: 长期接触二氧化硅粉尘对血清CC16和KL-6水平的影响
- Author:
Jing LIU
1
;
Rong ZHANG
;
Haiyan SONG
;
Qing XIA
;
Tongtong ZHAO
;
Liping PAN
;
Xiaolian QIAN
Author Information
1. Nanjing Prevention and Treatment for Occupational Disease, Nanjing 210042, China
- Publication Type:Journal Article
- Keywords:
Clara cell protein (CC16);
Serum Krebs von den Lungen-6 (KL-6);
Silica dust;
Silicosis
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(8):567-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of long-term exposure to silica dust on serum CC16 and KL-6 levels.
Methods:The patients with stage I silicosis who were hospitalized in our hospital from April 2016 to April 2017 were treated as silicosis group. The silica dust exposed workers without silicosis who were taken the physical examination in our hospital were taken as a dust-exposed group. The healthy control group comes from in the same period of community physical examination did not touch the dust. The levels of CC16 and KL-6 in serum of all subjects were determined by enzyme-linked immunosorbent assay (ELISA) , and the levels of CC16 and KL-6 in serum were compared in three groups.
Results:Compared with the control group, the serum levels of CC16 in the silicosis group (P<0.01) and the dust-exposed group (P<0.01) were significantly lower. Compared with the control group, the level of serum KL-6 in the silicosis group was significantly decreased (P<0.01) compared with the control group, while the level of KL-6 in the serum of the dust-exposed group was significantly increased (P<0.01) . The ROC area of CC16 for diagnosis of silicosis was 0.92 (P<0.01) , with a sensitivity of 81.37%, specificity of 92.63% and Kappa value of 0.74.
Conclusion:Long-term exposure to silica dust may lead to a decrease in serum CC16 levels. Reduced serum CC16 levels may be useful in identifying the diagnosis of silicosis.
