Analysis on the characteristics of suspected vaccine-related deaths in Fujian Province, 2012-2017
10.3760/cma.j.issn.0253-9624.2019.07.012
- VernacularTitle: 2012—2017年福建省疑似与预防接种有关的死亡病例特征分析
- Author:
Jianxiong XIAO
1
;
Zhiqiang LIN
;
Ruihong WU
;
Yong ZHOU
Author Information
1. Expanded Program Immunization Department of Fujian Center for Disease Control and Prevention, Fuzhou 350001, China
- Publication Type:Journal Article
- Keywords:
Vaccines;
Vaccination;
Adverse event following immunization;
Death;
Surveillance
- From:
Chinese Journal of Preventive Medicine
2019;53(7):719-723
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the characterisitics of the death cases suspected to be related to vaccination in Fujian Province from 2012 to 2017.
Methods:A total of 33 death cases information which was suspected to be related to the vaccinations from 2012 to 2017 were extracted from Chinese Adverse Events Following Immunization Information System (AEFI). The autopsy reports and the conclusions made by AEFI investigation diagnosis expert committee were collected at the same time. The inoculation data were obtained through the Fujian province Immunization Program Information System. The AEFI incidence, rare vaccine reaction incidences and mortality rates following immunization were figured out to analyze the characterisitics of the death cases associated with vaccination.
Results:The age of deuths cases was from 26 days to 52 months. Among 33 cases, 23 were males, and 8 were due to vaccine-related reaction, and the others were due to coincidental events. The number of rare vaccine reaction cases from 2012 to 2017 were 2,3,6,8,7 and 7, respectively. The highest AEFI incidence was measles and rubella combined attenuated live vaccine [38.88 (95%CI: 36.85-40.91)/100 000 dose], and the lowest was trivalent oral poliomyelitis attenuated live vaccine [2.01 (95%CI: 1.73-2.30)/100 000 dose]. The highest rare vaccine reaction incidence was measles and rubella combined attenuated live vaccine [15.04 (95%CI: 13.78-16.30)/100 000 dose], and the lowest was trivalent oral poliomyelitis attenuated live vaccine [0.38 (95%CI: 0.25-0.50)/100 000]. The highest mortality rate was inactivated poliomyelitis vaccine [0.26 (95%CI: 0.04-0.54)/100 000 doses], and the lowest mortality rate was measles, mumps and rubella combined attenuated live vaccine [0.01 (95%CI: 0.00-0.08)/100 000 doses]. The Spearman correlation analysis showed that there were correlations between AEFI incidence and rare vaccine reaction incidence (r=0.64, P=0.048), there were no correlations between AEFI incidence and mortality rate (r=-0.34, P=0.329), and there were no correlations between rare vaccine reaction incidence and mortality rate (r=-0.25, P=0.484).
Conclusion:Neither AEFI incidence nor rare vaccine reaction incidence was correlation with mortality rate. The main causes of death following vaccination were coincidental events.
