Association of abnormal metabolic indices and its clustering with carotid intima-media thickness in childhood
10.3760/cma.j.issn.0253-9624.2019.07.007
- VernacularTitle: 儿童期代谢指标异常及其聚集性与颈动脉内中膜厚度的关联研究
- Author:
Wang SHUI
1
;
Yanqing ZHANG
2
;
Yunfei ZHANG
1
;
Qian ZHANG
2
;
Min ZHAO
3
;
Bo XI
1
Author Information
1. Department of Epidemiology, School of Public Health, Shandong University/Children Cardiovascular Research Center of Shandong University, Ji′nan 250012, China
2. Department of Food Nutrition and Child Health Care, Zibo Center for Disease Control and Prevention, Zibo 255026, China
3. Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Ji′nan 250012, China
- Publication Type:Journal Article
- Keywords:
Child;
Nutritional and metabolic diseases;
Cross-sectional studies;
Carotid intima-media thickness
- From:
Chinese Journal of Preventive Medicine
2019;53(7):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association of abnormal metabolic indexes and its clustering with carotid intima-media thickness (cIMT) in childhood.
Methods:A convenient sampling method was used to conduct a cross-sectional survey from November 2017 to January 2018 in a primary school in Huantai County, Zibo City, Shandong Province. A total of 1 240 children who had complete data of questionnaires, physical examinations, and blood biochemical tests were included for analysis. Covariance analysis was used to analyze the association of the single abnormal metabolic indices and its clustering with cIMT. The multivariable linear regression model was used to quantify the relationship between the number of abnormal metabolic indices and cIMT.
Results:The age of 1 240 children was (8.9±1.5) years, and 657 boys accounted for 53.0%. The highest detection rate of abnormal metabolic indicators was found in abdominal obesity, accounting for 30.9% (203/657) of boys and 29.7% (173/583) girls respectively.The cIMT of boys and girls were (0.49±0.08) and (0.45±0.07) mm, respectively. After adjusting for sex, age, consumption of fruits, vegetables and carbonated drinks, sleep duration, screen time and physical activity, abdominal obesity, elevated blood pressure, total triglyceride and fasting glucose were associated with cIMT (all P values <0.001). Children with 0, 1, 2 and ≥3 abnormal metabolic indicators had cIMT values of (0.45±0.07), (0.48±0.08), (0.50±0.09) and (0.53±0.08) mm, respectively. That was, cIMT values increased with the number of abnormal metabolic indexes (Ptrend<0.001).
Conclusion:Abdominal obesity, elevated blood pressure, total triglyceride, fasting glucose and clustering of the above factors are associated with cIMT.
