Clinical significance and cost-benefit analysis of serum calcitonin assay in diagnosis and treatment of medullary thyroid carcinoma
10.3760/cma.j.issn.1673-0860.2019.07.005
- VernacularTitle: 血清降钙素检测对甲状腺髓样癌诊治的临床意义及成本效益分析
- Author:
Weijing HAO
1
;
Huan ZHANG
2
;
Yang YU
3
;
Jing ZHAO
4
;
Zhengjin GE
1
;
Puxun DING
1
;
Xiaoxuan SUN
1
;
Hong LIU
1
;
Shaoyan WEN
1
;
Jia YOU
1
Author Information
1. Department of General Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
2. Department of Prevention, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
3. Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
4. Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
- Publication Type:Journal Article
- Keywords:
Thyroid gland;
Carcinoma, medullary;
Calcitonin;
Cost-benefit analsis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(7):506-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical significance of serum calcitonin in the diagnosis and treatment of medullary thyroid carcinoma and to analyze its cost-benefit.
Methods:One hundred and forty one patients with medullary thyroid carcinoma who undertook calcitonin test and frozen pathological examination were enrolled in this study from Oct 2012 to Mar 2018. Using the method of χ2 test, the positive rate of calcitonin test and frozen pathological examination in diagnosis of medullary thyroid carcinoma(MTC) were compared. Firstly, we compared the correct checkout cost of calcitonin test and that of frozen pathological examination (total number of patients×cost of examination/the correctly detected number of patients) . Secondly, we calculated whether calcitonin test help patients save money(average cost of treatment in hospital for MTC×number of patients who were evaluated to be candidate for surgery-cost of calcitonin test×total number of patients)/total number of patients.
Results:139 patients were positive in calcitonin test among 141 patients, and the positive rate was 98.58%. 91 patients were positive in frozen pathological examination, and the positive rate was 64.54% (χ2=97.821, P<0.000 1) . Cost-benefit analysis showed that the correct checkout cost of calcitonin test and frozen pathological examination were 71.01 yuan and 426.10 yuan, also,1 371 938.64 yuan could be saved totally and 9 730.06 yuan could be saved per patient because of calcitonin test.
Conclusion:Serum calcitonin test had a significant effect on the diagnosis and treatment of medullary thyroid carcinoma and was economical and practical.
