Feasibility analysis of pepsin strip test in diagnosis of laryngopharyngeal reflux disease
10.3760/cma.j.issn.1673-0860.2019.07.004
- VernacularTitle: 胃蛋白酶试纸条检测诊断咽喉反流性疾病的可行性分析
- Author:
Jiasen WANG
1
;
Jinrang LI
1
;
Mukun WU
1
Author Information
1. Department of Otorhniolaryngology Head and Neck Surgery, Chinese People′s Liberation Army General Hospital-Six Medical Centre, Beijing 100048, China
- Publication Type:Journal Article
- Keywords:
Pepsinogens;
Laryngopharyngeal reflux;
pH monitoring
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(7):501-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the feasibility of pepsin strip test in the diagnosis of laryngopharyngeal reflux.
Methods:From August 2017 to September 2018,80 patients in Department of Otorhniolaryngology Head and Neck Surgery,Chinese People′s Liberation Army General Hospital-Six Medical Centre, underwent pepsin strip test and 24-hour multichannel intraluminal impedance(MII)-pH monitoring. The results of the two methods were analyzed for consistency,and 24-hour MII-pH monitoring was used as a statistical reference for the sensitivity and specificity of pepsin strip test in the diagnosis of laryngopharyngeal reflux. Data were analyzed by SPSS 19.0 software.
Results:There were 57 patients with positive pepsin test strip and 23 patients with negative pepsin test strip. The score of reflux symptoms and signs, and the positive rate of laryngopharyngeal reflux events in patients with positive pepsin strip test were significantly higher than those in patients with negative pepsin test strip. If there was one or more throat reflux events (including acid reflux,weak acid reflux and alkali reflux) as the positive results of 24-hour MII-pH monitoring,the consistency between the results of pepsin strip and 24-hour MII-pH was moderate (Kappa=0.614). The sensitivity and specificity of pepsin strip were 86.9% (53/61) and 78.9% (15/19) respectively.
Conclusions:Pepsin strip detection has the advantages of non-invasive,cheap and easy to operate.As an objective method for early diagnosis of laryngopharyngeal reflux, pepsin strip detectionis feasible,but can not be the final diagnosis for laryngopharyngeal reflux disease.
