Determination of aluminum in blood of occupational workers by ICP-MS
10.3760/cma.j.issn.1001-9391.2019.07.015
- VernacularTitle: 铝作业工人血液中铝测定的ICP-MS法
- Author:
Nan SHANG
1
;
Shuo WANG
2
;
Shanshan WANG
3
;
Han SUN
2
;
Xiujun QIN
4
;
Ping ZHANG
3
;
Rong FAN
3
;
Jin CHEN
3
;
Tao HUANG
3
;
Yanhong WANG
3
;
Qiao NIU
3
;
Qinli ZHANG
3
Author Information
1. School of Public Health, Shanxi Medical University, Taiyuan 030001, China; The First Hospital of Shanxi Medical University, Taiyuan 030001, China
2. Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100013, China
3. School of Public Health, Shanxi Medical University, Taiyuan 030001, China
4. School of Public Health, Shanxi Medical University, Taiyuan 030001, China; China Institute for Radiation Protection, Taiyuan 030006, China
- Publication Type:Journal Article
- Keywords:
Aluminum;
Occupational contact;
Blood;
Inductively coupled plasma mass spectrometry
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(7):540-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the determination of aluminum in blood, and to detect the aluminum content in the blood of occupational aluminum workers.
Methods:The morning blood of the aluminum workers was collected in an anticoagulation tube, and the supernatant was centrifuged. The supernatant was diluted with 4% nitric acid containing 1% Triton for 24 h at room temperature, and the supernatant was centrifuged. The supernatant was filtered and the blood aluminum concentration was measured by inductively coupled plasma mass spectrometry and quantified by external standard method.
Results:The detection limit of ICP-MS method was 0.39 μg/L, the linear range was 0-160 μg/L, the recoveries were 98.24%-99.65%, and the precision was 0.19%-0.28%. The recoveries of graphite furnace atomic absorption spectrophotometry (GFAAS) were 97.17%-111.18%, and the precision was 0.35%-0.44%. The average blood aluminum concentration of aluminum workers in the normal control group was (19.87±10.65) μg/L. The average blood aluminum concentration of aluminum workers in the expose group was (31.12±11.43) μg/L.
Conclusion:The method of ICP-MS for the determination of aluminum concentration in blood has a simple pretreatment process, high recovery rate, low detection limit and high precision, which is suitable for popularization.
