Effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia
10.3760/cma.j.issn.0253-9624.2019.06.006
- VernacularTitle: 不同来源ω-3多不饱和脂肪酸对2型糖尿病合并血脂异常人群糖脂代谢的影响
- Author:
Feng WANG
1
;
Hechun LIU
1
;
Xiaosong LIU
2
;
Shunan DONG
1
;
Da PAN
1
;
Ligang YANG
1
;
Guiju SUN
1
Author Information
1. Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China
2. Diabetes Specialist Clinic, Guanlin Hospital, Yixing 214251, China
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Dyslipidemias;
ω
-3 polyunsaturated fatty acid;
Glucolipid metabolism
- From:
Chinese Journal of Preventive Medicine
2019;53(6):570-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia.
Methods:We recruited participants from the diabetes specialist clinic at the Guanlin hospital in Yixing city, Jiangsu Province from February 2017 to March 2017. A total of 180 subjects were randomly assigned to 3 g/day fish oil (FO), perilla oil (PO), or fish oil mixed with linseed oil (FLO) for 6 months. The basic conditions and fasting venous blood sample were obtained from each study subject at baseline, after 6 months of intervention. Serum glucose and lipid metabolism were investigated.
Results:A total of 156 subjects aged (62.6±8.6) years completed the final follow-up after 6 months (FO,54 subjects; PO,52 subjects; FLO,50 subjects). Among them,59 patients (37.8%) were male. Serum glucose, glycated hemoglobin, C peptide, insulin and homeostasis model assessment-insulin resistance were not significantly different among the three groups after 6 months. Serum triglyceride decreased, whereas high-density lipoprotein cholesterol increased in FO [1.33 (1.05,1.93) mmol/L, (1.36±0.29) mmol/L, respectively] compared with PO [1.71 (1.23, 2.17) mmol/L, (1.23±0.22) mmol/L, respectively] and FLO [1.51 (1.12, 2.22) mmol/L, (1.29±0.30) mmol/L, respectively] (P<0.05). Serum low-density lipoprotein cholesterol and apolipoprotein B decreased in PO [(2.60±0.57) mmol/L,(0.96±0.23) g/L, respectively] compared with FO [(2.89±0.76) mmol/L, (1.07±0.30) g/L, respectively] (P<0.05). Serum lipoprotein(a) decreased in FLO [130.7 (63.3,270.6) mg/L] compared with FO [137.4 (58.7,333.2) mg/L] (P<0.05). Serum free fatty acid decreased in FLO [(0.43±0.15) mmol/L] compared with PO [(0.53±0.22) mmol/L] (P<0.05).
Conclusion:The effects of ω-3 PUFA from different sources on glucose metabolism in type 2 diabetic patients with dyslipidemia are similar. Each of them has a good application prospect in improving lipid metabolism.
