Research progress of deubiquitinating enzyme CYLD to regulate liver-related diseases
10.3760/cma.j.issn.1007-3418.2019.06.019
- VernacularTitle: 去泛素化酶圆柱瘤基因调控肝脏相关疾病的研究进展
- Author:
Xiao YANG
1
;
Dongjie AN
;
Chunchen GAO
;
Hongyan QIN
Author Information
1. Department of Medical Genetics and Developmental Biology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China
- Publication Type:Review
- Keywords:
Gene, cylindromatosis;
Ubiquitination;
Deubiquitinating enzyme;
Liver disease
- From:
Chinese Journal of Hepatology
2019;27(6):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Cylindromatosis gene is a kind of tumor suppressor genes, whose mutation or deletion will lead to the development of a cylindrical tumor. The deubiquitinating enzyme CYLD protein encoded by it is a member of the deubiquitinating enzyme family. CYLD alters the function of the target molecules by removing the ubiquitin chain linked to the substrate protein K63, and participates in the regulation of signaling pathways, such as NF-κB, JNK and Wnt. This article reviews the recent year’s research progress of CYLD, especially its negative regulatory role in the progression of liver-related diseases.
