Research progress of extracellular vesicles in hepatic fibrosis
10.3760/cma.j.issn.1007-3418.2019.06.003
- VernacularTitle: 细胞外囊泡在肝纤维化疾病中的研究进展
- Author:
Chenyang TAO
1
;
Jinsheng GUO
2
;
Yinghong SHI
1
Author Information
1. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital Affiliated Fudan University, Shanghai 200032, China
2. Division of Digestive Diseases, Zhongshan Hospital, Shanghai Institute of Liver Diseases, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Exosomes;
Extracellular vesicles
- From:
Chinese Journal of Hepatology
2019;27(6):407-410
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a pathophysiological process characterized by abnormal accumulation of connective tissues in the liver caused by chronic liver injuries, in which the activation and migration of hepatic stellate cells (HSCs) play a central role. Extracellular vesicles (EVs) are a class of nanoscale, bilayer lipid enveloped vesicles secreted by almost all cells. EVs are of great interest in liver pathology because they have been found to mediate the communication between cells and regulate cellular microenvironment via horizontal transfer of their cargoes. EVs carry bioactive cargoes including proteins, lipids and RNA molecules, and are involved in the activation of HSCs during liver fibrogenesis.