HIV-1 drug resistance and influencing factors among people living with HIV/AIDS before antiretroviral therapy in Liangshan Yi Autonomous Prefecture
10.3760/cma.j.issn.0254-6450.2019.06.009
- VernacularTitle: 凉山彝族自治州HIV/AIDS抗病毒治疗前HIV-1耐药情况及其影响因素分析
- Author:
Aobo DONG
1
,
2
;
Lin XIAO
3
;
Shu LIANG
4
;
Lei LIU
1
;
Ruihua KANG
1
;
Shuai ZHAO
1
;
Yuhua RUAN
1
;
Shuiling QU
5
;
Hui XING
1
Author Information
1. State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2. Third Hospital of Baotou City, Baotou 014040, China
3. Liangshan Yi Autonomous Prefecture Center for Disease Control and Prevention, Xichang 615000, China
4. Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China
5. Department of Education and Training, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
HIV-1;
Subtype;
Drug resistance;
Transmission network;
Influencing factors
- From:
Chinese Journal of Epidemiology
2019;40(6):648-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore HIV-1 drug resistance and influencing factors among people living with HIV/AIDS before antiretroviral therapy in Liangshan Yi Autonomous Prefecture (Liangshan).
Methods:Between January 1 and June 30, in both 2017 and 2018, a cross-sectional survey was conducted in Liangshan HIV-1 pol sequences were gathered and analyzed according to WHO Guidelines on HIV drug resistance surveillance of 2014. Both HyPhy 2.2.4 and Cytoscape 3.6.1 software were used to analyze the drug resistant strains of HIV-1 transmission network.
Results:A total of 464 people living with HIV/AIDS was recruited. The proportion of HIV-1 CRF07_BC subtype was 88.6% (411/464), with HIV-1 drug resistance rate was 9.9% (46/464). The HIV-1 drug resistance rates of non-nucleoside reverse transcriptase inhibitors (NNRTI), nucleoside reverse transcriptase inhibitors(NRTI) and protease inhibitors (PI) were 6.7% (31/464), 1.9% (9/464) and 0.4% (2/464) respectively. New recombinant strains of HIV-1 URF_01BC subtype was independently clustered according to the drug resistant mutation sites. Results from the multivariate logistic analysis showed that injected drug users group had higher risk on HIV-1 drug resistance (aOR=3.03, 95%CI:1.40-6.54) than heterosexual group among people living with HIV/AIDS.
Conclusions:HIV-1 drug resistance rate had already been in a high level before antiretroviral therapy was in place. The newly identified recombinant strains of HIV-1 URF_01BC subtype were independently clustered according to the drug resistant mutation sites. It was necessary to strengthen the prevention of the HIV-1 drug resistant strains transmission.
