Review on the etiology and complications of hand, foot and mouth disease, using data from the national sentinel surveillance program, in China, 2015-2016
10.3760/cma.j.issn.0254-6450.2019.06.005
- VernacularTitle: 我国2015－2016年哨点监测手足口病病原学和并发症分析
- Author:
Zhong ZHANG
1
,
2
;
Yaming ZHENG
3
;
Lili JIANG
4
;
Hong JI
5
;
Guoping CHEN
6
;
Ping LUO
7
;
Jingjing PAN
8
;
Xiaoling TIAN
9
;
Leilei WEI
10
;
Da HUO
11
;
Ziping MIAO
12
;
Xiaoni ZOU
13
;
Jianhua CHEN
14
;
Qiaohong LIAO
3
;
Zhaorui CHANG
3
Author Information
1. Nanjing Municipal Center for Disease Control and Prevention, Nanjing 210003, China
2. Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
3. Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on InfectiousDisease, Chinese Center for Disease Control and Prevention, Beijing 102206, China
4. Yunnan Provincial Center for Disease Control and Prevention, Kunming 650011, China
5. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
6. Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China
7. Shaoyang Municipal Center for Disease Control and Prevention, Shaoyang 422000, China
8. Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
9. Inner Mongolia Autonomous Region General Center for Disease Control and Prevention, Hohhot 010031, China
10. Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, China
11. Beijing Center for Disease Control and Prevention, Beijing 100013, China
12. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
13. Guangdong Women and Children Hospital, Guangzhou 511440, China
14. Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China
- Publication Type:Journal Article
- Keywords:
Hand, foot and mouth disease;
Sentinel surveillance;
Etiology;
Positive rate;
Complication
- From:
Chinese Journal of Epidemiology
2019;40(6):627-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the characteristics relating to the etiology and complications of hand, foot and mouth disease (HFMD) based on data from the pilot National Sentinel Surveillance (NSS) program so as to explore the feasibility, advantages and disadvantages of the NSS.
Methods:Data were extracted from the NSS system, conducted in 11 provinces of China from November 2015 to October 2016. Characteristics regarding the etiology, complications of HFMD and factors related to the positive rates of HFMD specimens were analyzed under the logistic regression method by SPSS 20.0 software.
Results:A total of 4 783 specimens were collected, including 3 390 from mild, 1 390 from severe and 3 from death cases. The overall positive rate was 81.43% (3 895/4 783). Other enteroviruses (non EV71/Cox A16 enteroviruses) appeared the major serotype (52.68%, 1 482/2 813) for mild infection of the disease while EV71 was for the severe cases (65.31%, 706/1 081). The serotype spectrum revealed by the pilot NSS was almost identical with the existing surveillance system. Other enteroviruses tended to infect younger children (χ2=130.17, P<0.001) than EV71 and Cox A16, in China. The multivariate logistic regression results showed that higher positive rate was associated with specimens which were collected from males, at children’ hospitals, in peak seasons, timely and in stools. The positive rates presented downwarding trends with the extension of the onset-sampling interval (χ2=14.47, P<0.001 in stool specimen; χ2=31.99, P<0.001 in throat swab; χ2=24.26, P<0.001 in anal swab). Aseptic meningitis, non-brainstem encephalitis and brainstem encephalitis appeared the top three complications of both EV71-associated and other enteroviruses-associated severe HFMD cases.
Conclusions:Factors as gender, season/place/timeliness of specimen collection, and types of hospital all appeared independently influenced the positive rates. NSS seemed feasible to be used as an alternative or supplement tool to the existing surveillance program in China.
