Correlations between striatal dopamine transporter distribution, glucose metabolism and clinical symptoms in Parkinson′s disease
10.3760/cma.j.issn.2095-2848.2019.06.006
- VernacularTitle: 帕金森病脑多巴胺转运体分布、葡萄糖代谢及临床症状评分的相关性
- Author:
Fangyang JIAO
1
;
Jun TAO
1
;
Jinju SUN
1
;
Haosu ZHANG
2
;
Yi LUO
1
;
Jianliang WEN
1
;
Zhenfan ZHAO
3
;
Zhiqiang XU
3
;
Rongbing JIN
1
Author Information
1. Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China
2. Neurochirurgische Klinik und Poliklinik, Technische Universitat München, Klinikum rechts der Isar, München 2281675, Germany
3. Department of Neurology, Daping Hospital, Army Medical University, Chongqing 400042, China
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Dopamine plasma membrane transport proteins;
Signs and symptoms;
Positron-emission computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(6):349-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations among striatal dopamine transporter (DAT) distribution, glucose metabolism and Parkinson′s disease (PD) clinical symptoms.
Methods:Twenty-five clinically confirmed idiopathic PD patients (17 males, 8 females, age: (59.8±9.2) years) who underwent 11C-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (CFT) and 18F-fluorodeoxyglucose (FDG) PET imaging from January 2015 to December 2016 were reviewed. The detailed clinical scores were systematically collected from all patients. Correlations between DAT distribution, glucose metabolism and clinical symptoms were evaluated at global and voxel levels using Pearson correlation analysis.
Results:There were significantly positive correlations between the PD-related pattern (PDRP) value and unified PD rating scale (UPDRS) motor scores, non-motor symptoms scale (NMSS) scores, activity of daily living scale (ADL) scores (r values: 0.580, 0.522, 0.557, all P<0.05). The CFT uptake of ipsilateral caudate nucleus, anterior putamen, and posterior putamen were negatively correlated with UPDRS motor scores (r values: -0.496, -0.492, -0.457, all P<0.05), while those had no significant correlations with NMSS scores (r values: -0.420, -0.402, -0.355, all P>0.05). The CFT uptake of ipsilateral caudate nucleus and anterior putamen were negatively correlated with ADL scores (r values: -0.502, -0.522, both P<0.05). There were no significant correlations between CFT uptake in contralateral striatal, anterior putamen, posterior putamen and PDRP values, UPDRS motor scores, NMSS scores and ADL scores(r values: from -0.466 to -0.129, all P>0.05). The presence of the significant correlations between UPDRS motor scores, ADL scores and the CFT radioactive count were confirmed in left caudate nucleus and left putamen (r values: from -0.90 to -0.47, all P<0.05). The metabolic PET imaging disclosed a set of brain regions correlating with the clinical symptoms. The presence of significant correlations between the metabolic PET imaging and CFT uptake were confirmed in bilateral caudate nucleus (r values: 0.47-0.90, both P<0.01), precentral gyrus and insula (r values: -0.90 to -0.47, all P<0.01).
Conclusion:The correlations between DAT distribution, glucose metabolism and PD clinical symptoms are complicated, which promote the understanding in the proper application of dopaminergic and metabolic PET imaging in PD and offer more evidences in PD pathophysiological mechanisms.
