Clinical characteristics of forty-four cases of acute HIV-1 infection
10.3760/cma.j.issn.1003-9279.2019.06.011
- VernacularTitle: 44例急性HIV-1感染者临床特征分析
- Author:
Bo LIU
1
;
Zhimin CHEN
1
;
Linghua LI
1
;
Baolin LIAO
1
;
Yun LAN
2
;
Lizhi FENG
1
;
Jiansheng ZHANG
1
;
Xiaoping TANG
2
;
Weiping CAI
1
;
Haolan HE
1
Author Information
1. Center of Infectious Disease, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510060, China
2. Guangzhou Institute of Infectious Disease, Guangzhou 510060, China
- Publication Type:Journal Article
- Keywords:
HIV-1;
Acute infection;
Clinical manifestation;
CD4+ T lymphocyte
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(6):611-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical, immunological and virological characteristics of HIV-1 infected patients in the acute phase, for the sake of improving the diagnosis of acute infection with HIV-1.
Methods:We retrospectively analyzed the clinical manifestation and laboratory data of patients with acute HIV-1 infection who were admitted to the Center of Infectious Diseases, Guangzhou Eighth People’s Hospital from January 2012 to June 2017.
Results:Forty-four patients were enrolled into the study, 86.4% of them were male. 59.1% patients were homosexually transmitted. Clinical symptoms and signs mostly consisted of fever (84.1%), lymphadenopathy (56.8%) and so on, while 15.9% patients had central nervous system symptoms. Most common opportunistic infection included lung infection (50.0%) and oropharyngeal candidiasis (22.7%). Leucopenia (10 patients, 22.7%), and decreased CD4+ T cell count (267.5 cells/μl), inverted CD4+ /CD8+ ratio (86.4%) was mostly seen. Compared to patients who had HIV RNA load less than 6 lg copies/ml, the group of patients who had HIV RNA load more than 6 lg copies/ml had lower levels of CD4+ T cells (t=-3.724, P=0.001).
Conclusions:Patients with acute HIV infection have many different kinds of clinical symptoms and can be accompanied by opportunistic infection, and with high viremia.
