Expression of galectin-1 in Chinese laryngeal squamous cell carcinoma patients and its clinical significance
10.3760/cma.j.issn.1003-9279.2019.06.002
- VernacularTitle: 半乳糖凝集素-1在喉鳞状细胞癌中的表达及其与人乳头瘤病毒表达的关系
- Author:
Wei WEI
1
;
Yuntao SONG
1
;
Guohui XU
1
;
Yuezhang WU
2
;
Liping GAO
2
;
Kang XIAO
2
;
Qi SHI
2
Author Information
1. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Head and Neck Surgery Department, Peking University Cancer Hospital & Institute, Beijing 100142, China
2. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Rd 155, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
Laryngeal squamous cell carcinoma;
Galectin-1;
Immunohistochemical technique
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(6):566-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression and clinical significance of galectin-1 in Chinese laryngeal squamous cell carcinoma patients.
Methods:Immunohistochemical technique was used to test the galecin-1 protein expression in the 50 laryngeal squamous cell carcinoma patients and Western blot method was used to test the galecin-1 protein expression in the 3 of the patients. SAS 9.4 software was used to analyze the relationship between the galectin-1 protein and the clinical degrees, pathological grades and lymph node metastasis in all the cases.
Results:In the 50 laryngeal squamous cell carcinoma patients, the positive rate of galectin-1 protein was 74% (37/50). The expression of galectin-1 protein was correlated with the severity of clinical staging, pathological differentiation and lymph node metastasis.
Conclusions:High expression of galectin protein related with the occurrence and development of head and neck squamous cell carcinomas.
