Botulinum toxin A poisoning by local aesthetic injection: clinical and electrophysiological analyses of 20 cases
10.3760/cma.j.issn.1671-0290.2019.06.013
- VernacularTitle: 局部注射A型肉毒毒素中毒20例的电生理分析
- Author:
Xiaolan JIN
1
;
Huaying CAI
2
;
Wen LYU
2
;
Hong JIANG
1
Author Information
1. EMG Room, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, China
2. Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, China
- Publication Type:Clinical Trail
- Keywords:
Botulinum toxins, type A;
Botulinum antitoxin;
Injections;
Electrophysiology
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2019;25(6):488-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical and electrophysiological characteristics of botulinum toxin A poisoning induced by local cosmetic injection, and to explore the possible pathogenesis.
Methods:Clinical data of 20 patients with botulinum toxin type A local cosmetic injection poisoning admitted to our hospital from January 2016 to December 2018 were collected and electrophysiological tests were carried out.
Results:The clinical manifestations of 20 patients were mainly 15/20 (75.0%) with limb weakness, and the proximal end was heavier than the distal 20/20 (100%), and the upper limb was heavier than the lower limb 26/20 (80%), followed by dysphagia 12/20 (60%), dysarthria 5/20 (25%), cervical muscle weakness 5/20 (25%), extraocular muscle paralysis 4/20 (20%), masseter muscle weakness 3/20 (15%) and respiratory muscle weakness 2/20 (5.0%) with respiratory failure 1/20 (5.0%). The results of neurophysiological examination showed the highest rate of SFEMG (90.0%), followed by RNS (80.0%), EMG (65.0%) and NCV (40.0%), suggesting that neuromuscular junction dysfunction was the main presentation. Patients who actively gave botulinum antitoxin injection therapy and symptomatic support treatment had good prognosis.
Conclusions:Local cosmetic injection of botulinum toxin type A may lead to poisoning. The symptoms of poisoning are mainly caused by limb weakness. Neuroelectrophysiological examination can assist in the diagnosis of botulinum toxin poisoning.
