P0 protein promotes the expression of INF-γ and IL-10 in peripheral blood of n-hexane neuropathy patients
10.3760/cma.j.issn.1001-9391.2019.06.008
- VernacularTitle: P0蛋白促进正己烷中毒性周围神经病患者外周血INF-γ和IL-10的表达
- Author:
Wei ZHOU
1
;
Guangtao YANG
;
Yingping XIANG
Author Information
1. Department of Occupational Health Assessment, Shenzhen Prevention and Treatment Center for Occupational Disease, Shenzhen 518020, China
- Publication Type:Case Reports
- Keywords:
Hexane;
Cellular immunity;
Enzyme-linked immunospot assay
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(6):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes of monocyte cytokines in peripheral blood of n-hexane neuropathy patients induced by P0 protein, and to explore the role of autoimmunity in n-hexane neuropathy patients.
Methods:In May 2018, 5 patients with peripheral neuropathy diagnosed as n-hexane poisoning were selected as case group in Shenzhen Prevention and Treatment Center for Occupational Disease in 2017. 6 workers exposure to n-hexane and 6 workers without n-hexane exposure were selected as contact group and control group. Peripheral blood mononuclear cells(PBMC) were isolated from venous blood.
Results:The number of spots produced by INF-γ and IL-10 increased after stimulation with P0 protein in case group, and the positive rate was significantly higher than control group and the contact group.
Conclusion:Autoimmunity induced by P0 protein may be involved in the occurrence of myelin sheath damage in n-hexane neuropathy patients.
