Association between polymorphisms of interleukin-17 genes and pneumoconiosis susceptibility
10.3760/cma.j.issn.1001-9391.2019.06.003
- VernacularTitle: 白细胞介素-17基因多态性与尘肺易感性研究
- Author:
Zheng ZHANG
1
;
Ying CHEN
;
Ke HAN
;
Huaibin WANG
;
Miaomiao WANG
;
Kun XIAO
;
Fuhai SHEN
Author Information
1. School of Public Health, North China University of Science and Technology, Tangshan 063210, China
- Publication Type:Journal Article
- Keywords:
Pneumoconiosis;
Interleukin-17;
Polymorphisms
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(6):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between polymorphisms of interleukin 17(IL-17) gene (rs4711998, rs763780) and the susceptibility of pneumoconiosis, and to provide a basis for prevention of high-risk groups of pneumoconiosis.
Methods:A total of 219 pneumoconiosis patients and 242 workers without pneumoconiosis were enrolled in the study. All subjects were photographed with high undulating X-rays anterior chest radiographs, diagnosed according to diagnostic criteria for pneumoconiosis. We collected 3 ml of peripheral venous blood of the study subjects. Polymorphism in IL-17A rs4711998 and IL-17F rs763780 locus were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:The IL-17A rs4711998 locus has AA, AG and GG genotypes, there was no the significant difference between case and control groups (P>0.05). IL-17F rs763780 had AA, AG and GG genotypes, there was a significant difference between case and control groups (P<0.05). Allele A and allele G were statistically significant difference between the case group and the control group (P<0.05).
Conclusion:No relationship was found between IL-17A gene polymorphisms at rs4711998 and silicosis. IL-17F rs763780 locus gene polymorphism is associated with susceptibility to pneumoconiosis. AG genotype and G allele may have a protective effect.
