Comparison of the ratio of plasma aldosterone to renin concentrationmeasured by two chemiluminescent immunoassays in screening for primary aldosteronism
10.3760/cma.j.issn.1674-6090.2019.06.002
- VernacularTitle: 比较两种化学发光法测定的血浆醛固酮/肾素浓度比值筛查原醛症的价值
- Author:
Zhixin XU
1
;
Ying SONG
1
;
Qianna ZHEN
1
;
Shumin YANG
1
;
Jinbo HU
1
;
Qifu LI
1
Author Information
1. Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Collective Name:Conpas Group;Chongqing Primary Aldosteronism Research Team, Chongqing 400016, China
- Publication Type:Journal Article
- Keywords:
Hyperaldosteronism;
Chemiluminescent immunoassay;
Renin;
Aldosterone
- From:
Chinese Journal of Endocrine Surgery
2019;13(6):445-449
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the detection efficiency of the ratio of plasma aldosterone concentration to renin concentration (ARR) measured by imported and domestic chemiluminescent immunoassay kits for screening primary aldosteronism (PA) .
Methods:A total of 164 patients with essential hypertension and 64 patients with PA were recruited in this study. Plasma aldosterone concentration (PAC) and renin concentration (PRC) were measured concurrently by imported chemiluminescent immunoassay kit (Diasorin, Italy) and domestic kit (Mindray, Shenzhen, China) , and then ARR were calculated. A ROC curve analysis was performed to compare the screening efficacy of the two kits and the optimal ARR cut-offs for PA screening were recommended according to Youden’s index.
Results:The areas under the ROC curves (AUCROC) of ARR were 0.937 (95% CI 0.897-0.965, P<0.0001) detected by imported kit and 0.942 (95% CI 0.903-0.968, P<0.0001) detected by domestic kit. The difference of AUCROC of ARR detected by two kits was 0.00457 (95% CI -0.0210-0.0302, P<0.7263) .The highest Youden’s indexes of ARR were 0.749 (detected by imported kit) with the cut-off value of 12.8 (pg/ml) / (μIU/ml) (sensitivity 96.87%, specificity 78.05%) and 0.756 (detected by domestic kit) with the cut-off value of 12.5 (pg/ml) / (μIU/ml) (sensitivity 89.06%, specificity 86.59%) .
Conclusions:There was no significant difference between domestic and imported chemiluminescent immunoassays in the screening efficiency of ARR for PA.
