Prevalence of severe fever with thrombocytopenia syndrome virus infection in Zhoushan island and duration of serum positive IgG antibody in infected patients
10.3760/cma.j.issn.1674-2397.2019.06.005
- VernacularTitle: 舟山海岛地区发热伴血小板减少综合征病毒流行情况及感染者IgG抗体持续时间分析
- Author:
Qiujing WANG
1
;
Ling YE
2
;
Zhe’en ZHANG
1
;
Zhejuan YANG
1
;
Yan WANG
1
;
Daiwen MAO
1
;
Lu WANG
1
;
Shibo LI
1
;
Feiyue WU
3
;
Peiyong ZHENG
4
Author Information
1. Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316012, Zhejiang Province, China
2. Daishan County Center for Disease Control and Prevention, Zhoushan 316200, Zhejiang Province, China
3. Department of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316012, Zhejiang Province, China
4. Internal Medicine of Traditional Chinese Medicine, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Bunyaviridae infections;
Severe fever with thrombocytopenia syndrome;
SFTSV-IgG antibody;
Epidemiology;
Latent infection
- From:
Chinese Journal of Clinical Infectious Diseases
2019;12(6):462-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence of severe fever with thrombocytopenia syndrome virus(SFTSV)infection in Zhoushan island of Zhejiang province and the duration of serum positive IgG antibody in patients infected with SFTSV.
Methods:One thousand one hundred and twenty-two healthy people from Zhoushan island of Zhejiang province were recruited for cross-sectional study in August 2019, including 641 from non-epidemic areas and 481 from epidemic areas. The serum SFTSV-IgG antibody was detected by enzyme-linked immunosorbent assay (ELISA), and the positive rates of SFTSV-IgG antibody were compared between people from the epidemic areas and non epidemic areas. Meanwhile, the antibody titer of SFTSV-IgG in 19 patients confirmed between July 2011 and June 2018 was detected by indirect ELISA. SPSS 17.0 software was used to analyze data.
Results:The positive rate of SFTSV-IgG antibody was 1.5% (7/481) in the epidemic area, which was higher than that in the non-epidemic area (0/641) (χ2=7.187, P<0.01). The positive rates of SFTSV-IgG antibody in 2019 were lower than those in the epidemic area (11.7%) and non-epidemic area (2.5%) in 2013 (χ2=22.556 and 10.352, both P<0.01). The serum SFTSV-IgG antibody of 18 patients with previous infection was still positive, and the longest one lasted for 8 years.
Conclusions:There is a SFTSV latent infection in population from epidemic area of Zhoushan island. The SFTSV-IgG antibody can last for a long time in patients with SFTS and it may have certain protective effect.
