Diagnostic value of combined detection of D-dimer and fibrinogen for malignant tumor with deep vein thrombosis
10.3760/cma.j.issn.1673-4181.2019.05.005
- VernacularTitle: D-二聚体和纤维蛋白原联合检测对恶性肿瘤合并深静脉血栓的诊断价值
- Author:
Shusheng HU
1
;
Xu WANG
;
Ruifang YANG
;
Xiaoyan WANG
;
Li REN
Author Information
1. Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
- Publication Type:Journal Article
- Keywords:
D-dimer;
Fibrinogen;
Deep venous thrombosis;
Tumors
- From:
International Journal of Biomedical Engineering
2019;42(5):388-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the levels of D-dimer (D-D) and fibrinogen (Fbg) in plasma of patients with malignant tumors, and to evaluate the diagnostic value of combined detection of D-D and Fbg.
Methods:The clinical data of 99 patients with malignant tumors were retrospectively analyzed, including 47 patients in DVT group and 52 patients in control group. DVT diagnosis was based on color Doppler or venography. The ROC curve was used to evaluate the diagnostic value of D-D, Fbg and the combination of D-D and Fbg for the malignant tumor patients with DVT.
Results:The D-D levels in the DVT group and the control group were 7.17 μg/ml and 4.25 μg/ml, respectively, and the Fbg levels were 4.01 mg/ml and 2.02 mg/ml, respectively, and the differences were statistically significant (all P<0.01). For the area under the ROC curve (AUC), specificity and sensitivity for diagnosing malignant tumors with DVT, D-D were 0.728, 62.50%, and 72.50%, respectively, and Fbg was 0.642, 65.50%, and 58.80%, respectively, and D-D+Fbg was 0.764, 83.30% and 59.00% respectively.
Conclusions:D-D and Fbg has a significantly high level in malignant tumor patients with DVT. The combined detection of D-D and Fbg has potential application value in the early diagnosis, early intervention and better prognosis for the malignant tumors patients with DVT.
