The relationship between hazard ratio and median survival time
10.3760/cma.j.issn.0253-9624.2019.05.021
- VernacularTitle: 风险比与中位生存时间的关系
- Author:
Miaochun CAI
1
;
Xianbo WU
;
Chen MAO
Author Information
1. Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
- Publication Type:Journal Article
- Keywords:
Regression;
Hazard ratio;
Median survival time
- From:
Chinese Journal of Preventive Medicine
2019;53(5):540-544
- CountryChina
- Language:Chinese
-
Abstract:
The hazard ratio and median survival time are the routine indicators in survival analysis. We briefly introduced the relationship between hazard ratio and median survival time and the role of proportional hazard assumption. We compared 110 pairs of hazard ratio and median survival time ratio in 58 articles and demonstrated the reasons for the difference by examples. The results showed that the hazard ratio estimated by the Cox regression model is unreasonable and not equivalent to median survival time ratio when the proportional hazard assumption is not met. Therefore, before performing the Cox regression model, the proportional hazard assumption should be tested first. If proportional hazard assumption is met, Cox regression model can be used; if proportional hazard assumption is not met, restricted mean survival times is suggested.
