The clinicopathologic parameters and prognostic analysis of vulvar squamous cell carcinoma
10.3760/cma.j.issn.0253-3766.2019.05.012
- VernacularTitle: 外阴鳞癌的临床病理特点及预后分析
- Author:
Tiantian WANG
1
;
Rong ZHANG
;
Hongwen YAO
;
Lingying WU
;
Shumin LI
;
Ping BAI
;
Hongjun LI
Author Information
1. Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Clinical Trail
- Keywords:
Vulvar squamous cell carcinoma;
Clinicopathologic parameters;
Prognosis
- From:
Chinese Journal of Oncology
2019;41(5):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the significance of different clinicopathologic features on prognosis of patients with squamous cell carcinoma of vulva.
Methods:We retrospectively analyzed the prognostic relevance of different clinicopathological variables of 201 patients with squamous cell carcinoma of vulva treated in Cancer Hospital, Chinese Academy of Medical Sciences. The data including age, initial symptoms, stage, location, tumor size, histological grade, number and size of metastatic lymph nodes, treatment mode, and presence of leukoplakia vulva was used to evaluate the prognosis of vulvar squamous cell carcinoma.
Results:The median age of onset was 62.0 years old, with 74 patients in stage Ⅰ, 27 in stage Ⅱ, 55 in stage Ⅲ and 9 in stage Ⅳ. The median progression-free survival was 90.0 months. The 5-year progression-free survival rate of the total patients was 55.5%, while the 10-year progression-free survival rate was 48.5%. Univariate analysis showed statistically significant prognostic parameters included clinical stage, number of metastatic lymph nodes, tumor size and treatment mode (all P<0.001). Multivariate analysis showed that number of metastatic lymph nodes (P<0.05) was an independent prognostic factor for progression-free survival.
Conclusion:The study illustrates that number of metastatic lymph nodes represents important independent factor for progression-free survival of patients with vulvar squamous cell carcinoma.
