HIV genetic subtypes and comparison of the first CD4+T cell counts in newly diagnosed HIV infected patients in Liuzhou, 1998-2012
10.3760/cma.j.issn.0254-6450.2019.05.017
- VernacularTitle: 柳州市1998－2012年新发现HIV基因亚型变化及HIV感染者首次CD4+T淋巴细胞计数比较
- Author:
Zhiqiang CAO
1
;
Wenmin YANG
2
;
Qiuying ZHU
2
;
Guanghua LAN
2
;
Zhiyong SHEN
2
;
Shujia LIANG
2
;
Jianjun LI
2
;
Huanhuan CHEN
2
;
Yi FENG
1
;
Xiang HE
3
;
Lingjie LIAO
1
;
Hui XING
1
;
Yuhua RUAN
1
;
Yiming SHAO
4
Author Information
1. National Center for ADIS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2. Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China
3. Guangdong Provincial Institute of Public Health, Guangzhou 511430, China
4. Peking University Health Science Center, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
HIV-1;
Genetic subtypes;
CD4+T cell counts
- From:Chinese Journal of Epidemiology
2019;40(5):580-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the change trend of HIV genetic subtypes and compare the first CD4+T cell counts of newly diagnosed HIV infected patients in Liuzhou from 1998 to 2012, and provide a reference for AIDS prevention and control.
Methods:Newly diagnosed HIV-infected patients from 1998 to 2012 in Liuzhou were selected through national HIV/ADIS comprehensive response information management system. Their plasma samples were used for RNA gene extraction, amplification, sequencing and genotyping. Coharan-Armitage trend test was used to analyze the ratio trend of genetic subtypes and phylogenetic clusters of HIV and Wilcoxon Rank Sum Test was used to compare the first CD4+T cell counts (CD4) of the different subtype HIV infected patients.
Results:A total of 1 877 newly diagnosed HIV infected patients were included in the study. From 1998 to 2012, the proportions of CRF01_AE and CRF01_AE (Cluster 1) increased from 78.4% (76/97) to 91.5% (1 441/1 574), from 63.9% (62/97) to 74.0% (1 164/1 574), and the proportion of CRF07_BC decreased from 17.5% (17/97) to 4.6% (72/1 574), respectively (Z=4.632, P<0.001; Z=2.455, P=0.014; Z=-5.943, P<0.001). The median and interquartile range of the first CD4 of the patients infected with subtype CRF01_AE (Cluster 1), CRF01_AE (Cluster 2), CRF07_BC and CRF08_BC were 230 (83-375), 215 (48-351), 365 (254-503) and 334 (206-479) cell/μl, respectively. The first CD4 levels of the patients infected with subtype CRF01_AE (Cluster 1) or CRF01_AE (Cluster 2) were significantly lower than those of CRF07_BC (Z=-4.795, P<0.001; Z=-4.238, P<0.001).
Conclusion:The genetic subtypes of HIV were mainly CRF01_AE in newly diagnosed HIV-infected patients and this subtype proportion was in increase and the first CD4 levels of the patients were low in Liuzhou during 1998 to 2012.
