Relationship between preterm birth of infant and medication during pregnancy in women of childbearing age in Shaanxi
10.3760/cma.j.issn.0254-6450.2019.05.012
- VernacularTitle: 陕西省育龄妇女围孕期用药与新生儿早产关系的研究
- Author:
Minmin LI
1
;
Chao LI
;
Binyan ZHANG
;
Wentao WU
;
Xiangyu GAO
;
Chenlu WU
;
Shaonong DANG
;
Hong YAN
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
- Publication Type:Journal Article
- Keywords:
Preterm birth;
Pregnancy;
Medicine
- From:
Chinese Journal of Epidemiology
2019;40(5):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the relationship between medication during pregnancy and single live preterm birth of infant in women of childbearing age in Shaanxi province.
Methods:A cross-sectional design was used in this study and stratified multistage random sampling method was used. A questionnaire survey was conducted in the childbearing-aged women selected through multi stage stratified random sampling in Shaanxi during 2010 to 2013. Qualitative datum was described by percentage and measurement datum was described by mean±standard deviation. Logistic regression analysis was done to evaluate the relationship between medication during pregnancy and preterm birth of infant.
Results:The overall incidence rate of premature birth was 2.7% in Shaanxi. Among the 28 841 mothers participating in this study, the proportion of medication use at any time during pregnancy was 15.8%, and the most commonly used drug was cold medicine (5.9%). After adjusting all confounding factors, the multivariable logistic regression analysis results showed that taking hormone medicine (OR=2.23, 95%CI: 1.19-4.18), antihypertensive medicine (OR=7.74, 95%CI: 4.28-13.95) and other medicines (OR=2.15, 95%CI: 1.60-2.89) during early pregnancy were the risk factors for preterm delivery, the risk was 2.23 times, 7.74 times and 2.15 times higher compared with those taking no these medicines.
Conclusion:Using hormone medicine, antihypertensive medicine and other medicines during pregnancy increased the risk for preterm delivery in women of childbearing age in Shaanxi.
