Prospective study of relationship between metabolic diseases and stroke in Jinchang Cohort
10.3760/cma.j.issn.0254-6450.2019.05.006
- VernacularTitle: 金昌队列人群代谢性疾病与脑卒中发病关系前瞻性研究
- Author:
Xiaoyu REN
1
;
Dian SHI
2
;
Desheng ZHANG
3
;
Jiao DING
3
;
Haiyan LI
3
;
Ting GAN
1
;
Ruiyang PU
2
;
Yana BAI
1
;
Ning CHENG
2
Author Information
1. Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China
2. School of Basic Medical, Lanzhou University, Lanzhou 730000, China
3. Workers’ Hospital of Jinchuan Group, Jinchang 737100, China
- Publication Type:Journal Article
- Keywords:
Jinchang Cohort;
Stroke;
Incidence;
Metabolic diseases;
Metabolic indexes
- From:
Chinese Journal of Epidemiology
2019;40(5):521-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the incidence of stroke in the population of Jinchang Cohort and the relationship between metabolic diseases and stroke, and provide scientific evidence for the prevention and treatment of stroke in the population.
Methods:The epidemiological investigation data and physical examination data of the 33 042 follow-up participants in Jinchang Cohort were collected for a prospective cohort study. Restricted cubic splines functions was used to analyze the dose-response relationship between metabolic indexes and the risk of stroke incidence.
Results:1) The incidence rate of stroke in Jinchang Cohort was 1.59%, and the standardized incidence rate was 3.99%. 2) Hypertension (male HR=2.20, female HR=4.45) and dyslipidemia (male HR=1.49, female HR=1.79) were the risk factors of stroke incidence in the population and diabetes had influence on the incidence of stroke only in the males (HR=1.79), while obesity had influence only in the females (HR=1.64). The more kinds of metabolic diseases, the higher risk of stroke incidence was. 3) Systolic blood pressure had a non-linear dose-response correlation with the risk of stroke incidence, while diastolic blood pressure had a positive linear correlation with the risk of stroke incidence.
Conclusions:The incidence of stroke in Jinchang Cohort population was high compared with both domestic level and oversea level. The patients with metabolic diseases were the population at high-risk for stroke, and more attention should be paid to them in the prevention and treatment of stroke. Diastolic blood pressure might be more closely related to stroke.
