Association between mitochondrial haplogroups and neurocognitive disorder in HIV positive individuals
10.3760/cma.j.issn.0254-6450.2019.05.003
- VernacularTitle: HIV感染者线粒体单倍群与神经认知障碍的关联研究
- Author:
Dan ZHAO
1
;
Haijiang LIN
2
;
Qian WEI
1
;
Xiaoxiao CHEN
2
;
Chenxi NING
1
;
Xiaotong QIAO
1
;
Yuanyuan XU
2
;
Weiwei SHEN
2
;
Yingying DING
1
;
Na HE
1
Author Information
1. Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
2. Taizhou Prefectural Center for Disease Control and Prevention, Taizhou 318000, China
- Publication Type:Journal Article
- Keywords:
HIV;
Mitochondrial haplogroups;
Neurocognitive disorders
- From:
Chinese Journal of Epidemiology
2019;40(5):505-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution of mitochondrial haplogroups and their correlation with neurocognitive disorder (NCD) in HIV positive individuals.
Methods:Baseline data were from the prospective cohort study of comparative HIV and aging research in Taizhou of Zhejiang province from January to December, 2017. A cross-sectional survey was performed in 448 HIV positive individuals. Sanger method was used for the sequencing and genotyping of whole mitochondrial genome of HIV positive individuals. NCD prevalence in the HIV positive individuals was assessed by Mini-mental State Examination (MMSE) in questionnaire interviews. Multivariable logistic regression analysis was performed to assess the associations between mtDNA haplogroups and NCD.
Results:In this sample, mitochondrial haplogroups D (19.6%, 88/448), B (19.4%, 87/448) and F(17.0%, 76/448) were the most predominant haplogroups. The overall prevalence rate of NCD was 20.3% (91/448), and was high in haplogroups A (23.1%, 9/39), D (21.6%, 19/88), F (26.3%, 20/76) and M7 groups (26.1%, 12/46), respectively. In multivariable logistic regression analysis after adjusting confounding factors, such as age and gender, compared with haplogroup A, there were no differences in the prevalence rate of NCD among HIV positive individuals with haplogroup B, D, F, M7, M8, N9, and others.
Conclusion:The study explored primarily correlation between mitochondrial haplogroups and NCD among HIV positive individuals and suggested that there is no significant association between mitochondrial haplogroups and NCD, but further longitudinal investigation with large sample size of HIV positive population is needed to confirm this finding.
