Research progress in genetics of congenital microtia
10.3760/cma.j.issn.1009-4598.2019.05.018
- VernacularTitle: 先天性小耳畸形遗传学研究进展
- Author:
Rui GUO
1
;
Ling ZHANG
;
Qinghua YANG
Author Information
1. Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
- Publication Type:Review
- Keywords:
Congenital microtia;
Genetics;
Etiology
- From:
Chinese Journal of Plastic Surgery
2019;35(5):507-512
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of congenital microtia are the result of multiple factors and mechanisms, including genetic factors, living environment and lifestyle, etc. However, genetics is the key to understand the etiology of congenital microtia. In this paper, the genetics of microtia was reviewed in the aspects of epigenetics, gene polymorphism, chromosomal change, genetic change and signal pathway. The etiology of microtia was discussed and summarized.
