The application of the concept of parabiotic tissue protection in the repair of acute radiation-induced skin injury
10.3760/cma.j.issn.1009-4598.2019.05.010
- VernacularTitle: 间生态组织保护理念在急性放射性皮肤损伤修复中的应用
- Author:
Daojiang YU
1
;
Tianlan ZHAO
1
;
Yulong LIU
2
;
Youyou WANG
2
;
Shuai WANG
1
;
Shuyu ZHANG
3
;
Jianping CAO
3
Author Information
1. Department of Plastic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
2. Nuclear Emergency Response Center, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
3. School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China
- Publication Type:Clinical Trail
- Keywords:
Acute radiation-induced skin injury;
Repair;
Surgical flap;
Parabiotic tissue
- From:
Chinese Journal of Plastic Surgery
2019;35(5):465-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the parabiotic tissue protection concept in the repairment of acute radiation-induced skin injury.
Methods:Seven patients(3 males and 4 females) with acute radiation injury treated in the Department of Plastic Surgery of the Second Affiliated Hospital of Soochow University from February 2014 to January 2018. The ages of patients ranged from 45 to 76 years. The wound areas include perineum and buttock (n=3), chest(n=2), and thigh(n=2). In the early stage, subregional " sandwich" surgical dressing was used to protect the probiotic tissue. Two months later, the necrotic tissue was clearly demarcated, the debridement was underwent, and the parabiotic tissue was preserved as far as possible. Vacuum sealing drainage(VSD)was applied to cover and soak wound with normal saline to moisturize the wound and promote the benign transformation of ecological tissue. Ten days later, the granulation grown well, and the skin flaps and myocutaneous flaps with good blood supply were designed to repair the wounds. The VSD device was continued to be used, to drain effusion under flap and promote the growth of cystic cavity granulation, with the purpose to promote blood supply of the skin flap, perform the final biological cleaning effect on the parabiotic tissue of the wound surface, promote the benign transformation of parabiotic tissue, and reduce the further necrosis.
Results:Seven patients with Ⅳ degree acute radiation-induced injury wounds were treated 6-10 weeks for surgery preparation, and 2-4 weeks for VSD-application after debridement. Except for part of flap was necrotized on 10th day after the first operation in one patient, all the other patients achieved satisfied outcome in a surgery. There was no further radiation-induced ulcer occurred during the 0.5-3 years of follow-up.
Conclusions:The concept of parabiotic tissue protection during preoperative, intraoperative and postoperative recovery phase can promote parabiotic tissue transformed to a good result after acute radiation injury, and reduce the size and depth of soft tissue necrosis, which can provide a good foundation for the secondary repair with flap and reduce complications.
