Circulating tumor cells in pancreatic cancer patients: progression in the detection methods and clinical application
10.3760/cma.j.issn.0529-5815.2019.05.015
- VernacularTitle: 胰腺癌循环肿瘤细胞检测及临床应用进展
- Author:
Xudong ZHAO
1
;
Yongsu MA
;
Xiaodong TIAN
;
Yinmo YANG
Author Information
1. Department of General Surgery, Peking University First Hospital, Beijing 100034, China
- Publication Type:Review
- Keywords:
Pancreatic cancer;
Neoplastic cells, circulating;
Detection methods;
Clinical application
- From:
Chinese Journal of Surgery
2019;57(5):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Circulating tumor cells (CTC) disseminate from primary tumors by undergoing epithelial mesenchymal transition that allow their entry into the circulation to drive metastatic formation in pancreatic cancer patients.Technological advances in detection and characterization of CTC are conducive to the early diagnosis, differential diagnosis, monitoring disease progression and predicating the probability of canceration or the chemotherapeutic efficacy. Nowadays, detection methods of CTC can be based on immunomagnetic beads technique, cell filtration or microfluidic chips technology, but there are great differences in the sample throughput, CTC recovery rate, purity, and CTC viability among them.Owing to the dilemma in detection methods, the intrinsic relevance between the biological characteristics of CTC and clinical manifestations is still not exactly elucidated. By the improved methodology, next generation sequencing technology and exploring the technique for culturing CTC in vitro and establishing xenotransplanted tumor model in nude mice, more and more biological information will be revealed, and finally, individualized treatment is achieved.
