Determination of diphenylmethane diisocyanate in workplace air by HPLC with impregnated filter membrane
10.3760/cma.j.issn.1001-9391.2019.05.017
- VernacularTitle: 工作场所空气中二苯基甲烷二异氰酸酯浸渍滤纸采集-高效液相色谱法
- Author:
Xiang WANG
1
;
Zubing WANG
;
Zhonglin ZHAO
Author Information
1. Shanghai Institute of Occupational Safety & Health, Shanghai 200041, China
- Publication Type:Journal Article
- Keywords:
Diphenylmethane diisocyanate;
Impregnated filter membrane;
HPLC
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(5):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a method for determining diphenylmethane diisocyanate in workplace air by HPLC with impregnated filter membrane.
Methods:MDI in workplace air reacted with 1- (2-pyridyl) piperazine on impregnated filter membrane to form MDI-urea derivatives, after elution and filtration, it was detected by HPLC-UV.
Results:Limit of detection was 0.003 8 μg/ml and limit of quantification was 0.013 μg/ml. Good linearity was obtained in the range of 0.013~2.000 μg/ml (r=0.999 7) . The precision was 3.10%~8.03% (n=6) , while the recovery was 96.3%~101.9%. Asorption capacity of the membrane was 40.8 μg MDI, and could be stored for 14 days in the light-proof environment of 2~8 ℃.
Conclusion:The method optimized testing steps for MDI's standard curve, and provided good guidance for determination of MDI in workplace air with impregnated fiter membrane.
