A study on measles and rubella antibody level in 319 pairs of mothers and infants in Songjiang District of Shanghai
10.3760/cma.j.issn.0253-9624.2019.04.011
- VernacularTitle: 上海市松江区319对母婴麻疹和风疹抗体水平研究
- Author:
Qi ZHU
1
;
Tajing HU
;
Jingwen SHEN
;
Jinhua SHEN
;
Wenhua CHEN
;
Shikang GU
;
Hongmei LU
Author Information
1. Immunoprophylaxis Department, Songjiang District Center for Disease Control and Prevention, Shanghai 201620, China
- Publication Type:Journal Article
- Keywords:
Measles;
Rubella;
Mothers and infants;
Antibody
- From:
Chinese Journal of Preventive Medicine
2019;53(4):388-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore serum levels of measles and rubella IgG antibodies among mothers and infants.
Methods:According to the inclusion and exclusion criteria, we selected 319 puerperae and their infants in maternal hospitals of Songjiang district November 2016 to February 2017, venous blood were collected and serum measles and rubella IgG antibodies were measured using ELISA. To study the correlation between the level of measles and rubella antibodies in infants and mothers′ by using the Spearman′s correlation analysis.
Results:The age at delivery was (29.71±4.25) years old; and the gestational age at delivery was (39.06±1.30) weeks. The positive rate and protection rate of measles antibody in puerperae were 82.5% (243/319) and 43.3% (135/319), the GMC [M (QR)] was 655.74 (251.21-1 299.02) mIU/ml. The positive rate of rubella antibody in puerperae was 61.1% (195/319), the GMC [M (QR)] was 31.34 (11.65-73.61) IU/ml. The positive rate and protection rate of measles antibody in infants were 84.1% (270/321) and 46.1% (148/321), the GMC [M (QR)] was 665.07 (279.63-1 544.07) mIU/ml. The positive rate of rubella antibody in infants was 69.5% (223/321), the GMC [M (QR)] was 40.30 (16.12-98.48) IU/ml. There was statistical difference in measles (Z=-14.64, P<0.001) and rubella (Z=-8.66, P<0.001) antibody levels between mothers and infants. There was positive correlation in measles (r=0.76, P<0.001) and rubella (r=0.86, P<0.001) antibody level between mothers and infants.
Conclusion:The maternal antibody of measles and rubella had a concentration effect. The level of measles and rubella antibodies in the infants was higher than that in the mothers′ and increased with the increase of the level of measles and rubella antibodies in the mothers.
