The study of exposure levels of dioxin-like compounds in cord blood of newborns in an e-waste dismantling area in Guangdong Province
10.3760/cma.j.issn.0253-9624.2019.04.007
- VernacularTitle: 广东省某电子垃圾拆解区新生儿脐带血中二噁英类化合物暴露水平研究
- Author:
Daichun LIU
1
;
Xijin XU
1
;
Xiangbin ZHENG
1
;
Yousheng JIANG
2
;
Jianqing ZHANG
2
;
Xia HUO
3
Author Information
1. Laboratory of Environmental Medicine and Developmental Toxicolog, Shantou University Medical College, Shantou 515041, China
2. Persistent Organic Pollutants Research Laboratory, Shenzhen Municipal Center for Disease Control and Prevention, Shenzhen 518055, China
3. Laboratory of Environmental Medicine and Developmental Toxicology, Jinan University, Guangzhou 510632, China
- Publication Type:Journal Article
- Keywords:
Electronic waste;
Fetal blood;
Dioxin-like compounds
- From:
Chinese Journal of Preventive Medicine
2019;53(4):365-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pollution status of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCB), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in cord blood of newborns in an e-waste dismantling area of Guangdong Province.
Methods:We recruited 20 eligible mothers and newborns who could meet the inclusion criteria in local hospitals of Guiyu in 2007. The inclusion criteria included directly engaged in dismantling e-waste during pregnancy and within 1 year before pregnancy; living in the e-waste dismantling workshops or the distance between living place and the e-waste dismantling areas was ≤200 m; the father of newborn was directly engaged in electronic waste dismantling for more than 1 year; the frequency of visiting the e-waste dismantling workshop during pregnancy was ≥3 times in a week. Questionnaires and physical examinations were performed on maternal and neonatal, and cord blood was collected from newborns to detect PCDD/Fs, PCB and PBDE. The concentration level of organic pollutants was corrected by the blood lipid content, and the total toxicity equivalent was calculated. The correlation between three compounds was analyzed by Spearman correlation.
Results:The mothers of the 20 newborns were (23.45±3.27) years old and lived for more than 5 years. The number of one parent engaged in e-waste dismantling, the mother or father smoking, and parent engaged in e-waste dismantling work were 3, 13, 15 and 19, respectively. The weight of newborns ranged from 2.5 to 3.6 kilogram and the Apgar score was 10 points. No adverse birth outcomes such as preterm birth, malformation or stillbirth were found. The median (maximum, minimum) concentration of PCBs, PCDD/Fs and PBDEs in cord blood were 263.22 (328.29, 244.19), 38.42 (147.49, 12.68), 39.33 (265.11, 14.81) pg/g lipid, respectively. The median (maximum, minimum) of toxic equivalence concentrations of PCDD/Fs and PCB were 3.94 (9.24, 2.69) and 15.95 (26.64, 9.28) pg TEQ/g lipid. PBDE, the proportion of PBDE, PCB and PCDD/Fs in cord blood was 50.41%, 49.25% and 0.34%, respectively. PCBs and PBDEs were positively correlated (r=0.733, P=0.039).
Conclusion:The high concentrations of PCDD/Fs, PCB, and PBDE were detected in the e-waste dismantling area. It is recommended that the risk of such substances on the health of local people should be assessed in a timely manner.
