Advances in liver immunology in 2018
10.3760/cma.j.issn.1007-3418.2019.04.001
- VernacularTitle: 2018年肝脏免疫学研究若干进展
- Author:
Jun WU
1
;
Yanqin DU
;
Dongliang YANG
Author Information
1. Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis C virus;
Innate immunity;
Adaptive immunity
- From:
Chinese Journal of Hepatology
2019;27(4):241-243
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of innate and adaptive immune responses to chronic infections with hepatotropic viruses (HBV, HCV) was studied in 2018. Its mechanism elucidated the dysregulation of natural killer (NK) cells, monocytes, B cells and T cells. In addition, a new target for immune regulation of HBV infection (TLR3/OX40L) was introduced. The discovery of new NK cell immune checkpoints, the involvement of mononuclear macrophages in liver failure and inflammation, sex hormone affecting intrahepatic-resistant bacterial infection through the regulation of humoral immunity, and the communication mechanism between liver and other immune organs have enriched people's understanding of liver immunology and its clinical significance.
