Clinical Characteristics and Short-term Treatment Response in Patients with Obsessive-Compulsive Disorder.
- Author:
Chan Hyung KIM
1
;
Min Seong KOO
;
Ho Suk SUH
;
Yoon Shick SHIN
;
Jang Woo KIM
;
Keun Ah CHEON
;
Yoon Yong NAM
;
Hong Shick LEE
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Obsessive compulsive disorder;
Clinical courses;
Subtype;
Comorbidity;
Short term response
- MeSH:
Ambulatory Care Facilities;
Anxiety Disorders;
Comorbidity;
Humans;
Mood Disorders;
Obsessive-Compulsive Disorder*;
Outpatients;
Personality Disorders;
Serotonin Uptake Inhibitors
- From:Korean Journal of Psychopharmacology
2003;14(3):206-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to describe and evaluate the clinical data and short-term treatment response in patients with obsessive-compulsive disorder (OCD) based on an outpatient setting. METHODS: A group of patients with OCD underwent mean 12-weeks treatment with selective serotonin reuptake inhibitors. The patients were divided into two groups according to treatment response, defined as a reduction of the Yale-Brown Obsessive Compulsive Scale total score >35% and CGI of 1 or 2. RESULTS: 1) Among the 249 patients, 24.1% had checking type and 23.7% washing type. Among these two types, 31.9% had mood disorder, 15.0% had anxiety disorder and 24.5% personality disorder as co-morbidity. One hundred fourteen patients (45.8%) responded to the treatment and 135 (54.2%) did not. The responders decreased Y-BOCS scores from 27.9+/-7.2 at baseline to 21.3+/-6.4 and 19.3+/-3.8 at post-treatment 8 and 12 weeks, respectively (repeated measure ANOVA, p=0.039). There were no differences among the treatment responses to serotonin reuptake inhibitors. CONCLUSION: About half of the OCD patients showed a response to pharmacological treatment using SSRI in the outpatient clinic setting for 12 weeks. Long-term and contrast studies of OCD may elucidate further clinical aspects of this disorder in the future.
