Dose-response relationship between maternal hemoglobin concentration and preterm birth, in pregnant women
10.3760/cma.j.issn.0254-6450.2019.04.019
- VernacularTitle: 孕妇血红蛋白浓度与早产关联强度剂量反应关系
- Author:
Liangjia WEI
1
;
Shun LIU
;
Dongping HUANG
;
Xuefeng GUO
;
Na WANG
;
Yonghong SHENG
;
Meile MO
;
Jun LIANG
;
Yanye SONG
;
Xiaoqiang QIU
Author Information
1. Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China
- Publication Type:Clinical Trail
- Keywords:
Hemoglobin;
Preterm birth;
Dose-response relationship;
Restricted cubic spline
- From:
Chinese Journal of Epidemiology
2019;40(4):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dose-response relationship between hemoglobin concentration and preterm birth, during pregnancy.
Methods:With Zhuang ethnicity, a total of 12 780 pregnant women and their infants that admitted to Wuming、Pingguo、Jingxi、Debao、Longan and Tiandong hospitals, were recruited, in Guangxi Zhuang Autonomous Region, from January 2015 to December 2017. Non-conditional logistic regression method was used to analyze the effect of anemia on preterm birth during pregnancy. Dose-response relationship between hemoglobin concentration and preterm birth was explored, using the restrictive cubic spline model.
Results:After excluding 2 053 pregnant women with hypertension or aged 35 years and over, results from the non-conditional logistic regression analysis showed that the risk of preterm birth in the anemia group was 1.29 times (OR=1.29, 95%CI: 1.04-1.59, P=0.019) of the non-anemia group in the first trimester. Data from the restricted cubic sample showed that there appeared nonlinear "L" dose-response relationship between hemoglobin concentration and preterm birth in the first trimester and "U" shape in the third trimester (non-linearity test P<0.001).
Conclusion:There appeared nonlinear dose-response relationship between the hemoglobin concentration and preterm birth, both in the first and third trimesters.
