Chitosan membrane type under the negative pressure therapy for infected wounds multi-resistant bacteria flora changes of examination
10.3760/cma.j.issn.1009-4598.2019.04.015
- VernacularTitle: 甲壳胺膜负压封闭引流疗法治疗多重耐药菌感染创面
- Author:
Qinghai DI
1
;
Jiacheng ZHANG
;
Yanzi WANG
;
Weizhi XU
;
Xiufeng GE
;
Jing WANG
Author Information
1. Department of Burns and Plastic Surgery, Jiaozhou Central Hospital of Qingdao, Qingdao 266300, China
- Publication Type:Journal Article
- Keywords:
Chitosan membrane;
Negative pressure;
Multiple resistant bacteria;
Infection wounds;
Bacterial biofilm
- From:
Chinese Journal of Plastic Surgery
2019;35(4):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the outcome of negative pressure closed drainage with chitosan membrane in the treatment of multiple drug-resistant bacterial infections.
Methods:From January 2015 to December 2017, 108 patients with skin ulcer wound complicated by multiple drug-resistant bacterial infection were admitted in the department of burn and plastic surgery, Qingdao Jiaozhou Central Hospital. Among them, 36 patients had pressure ulcers, 40 cases had diabetic foot wounds, and 32 were traumatic skin ulcer wounds. Patients were divided into group A or group B for different treatments. In group A, besides the basic surgical dressing change, patients were treated by negative pressure closed drainage with chitosan membrane. The patients in Group B were only treated with basic surgical dressing change. The changes of wound were closely observed during the phases, and the wound bacterial culture and antimicrobial drug sensitivity test were performed regularly. The therapeutic effects of the 2 groups were compared. The changes of bacterial species of wound infection and the healing time were recorded.
Results:In group A, the healing time of wound infection was: pressure ulcers (14.00±1.28) days, diabetic foot wounds (13.40±1.27) days, traumatic skin ulcer wounds (12.44±1.55) days. In group B, the wound healing time was: pressure ulcers (25.17±2.73) days, diabetic foot wounds (23.85±1.73) days, traumatic skin ulcer wounds (19.81±1.94) days. The wound healing time of group A was shorter than group B. In group A, the multiple drug-resistant bacteria was replaced by non-multiple drug-resistant bacteria, or there was no pathogenic bacterial growth. The differences between the two groups was statistically significant (all P<0.05).
Conclusions:Additional to the basic surgical dressing change, negative pressure closed drainage with chitosan membrane could promote wound healing, when it′s associated with multiple drug-resistant bacteria infection. This method has benefits in efficient drainage, preventing the formation of bacterial biofilm and changing local microenvironment for the dominant propagation. Therefore, it could effectively control the multiple drug-resistant bacterial infections, promote wound healing and save treatment time.
