MSCs in wound repair ——extracellular vesicles exosome microenvironment hypothesis
10.3760/cma.j.issn.1009-4598.2019.04.002
- VernacularTitle: 间充质干细胞与创面修复——间充质干细胞微环境细胞外囊泡假说
- Author:
Zairong WEI
1
;
Dali WANG
Author Information
1. Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Wound repair;
Extracellular vesicles;
Exosome;
Microenvironment;
Hypothesis
- From:
Chinese Journal of Plastic Surgery
2019;35(4):324-330
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells(MSCs) are currently the research hotspot on promoting wound healing and preventing organ fibrosis. The application of MSCs has reached the clinical trial stage, however, its nomenclature and biological mechanism are still controversial. Early researchers believed that MSCs play the biological role by its multi-directional differentiation, to repair damaged tissues. In recent years, researchers have found that the conditioned medium of MSCs has the same effect as MSCs in promoting wound healing and preventing fibrosis organ. This suggested that the biological effects of MSCs may be mainly caused by its paracrine mechanism. In this paper, the nomenclature evolution, biological mechanism of MSCs, and the existing problems are briefly reviewed. The hypothesis of " MSCs microenvironment extracellular vesicles" is proposed and discussed.
