The predictive accuracy of fine needle aspiration and BRAF V600E mutation in diagnosis of papillary thyroid carcinoma
10.3760/cma.j.issn.0529-5815.2019.04.012
- VernacularTitle: 细针穿刺标本BRAF V600E基因突变预测甲状腺乳头状癌的准确信度研究
- Author:
Xing YU
1
;
Yong WANG
;
Qiuping XIE
;
Haichao YAN
;
Qunzi ZHAO
;
Maolin ZHANG
;
Cheng XIANG
;
Ping WANG
Author Information
1. Department of Thyroid Surgery, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Mutation;
Biopsy, needle
- From:
Chinese Journal of Surgery
2019;57(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the predictive accuracy of fine needle aspiration (FNA) and BRAF V600E mutation in distinguishing papillary thyroid carcinoma and other thyroid nodules.
Methods:This retrospective cohort study included 93 patients with papillary thyroid carcinoma who treated at Department of Thyroid Surgery, the Second Affiliated Hospital of Zhejiang University, College of Medicine from September 2016 to May 2018. There were 21 males and 72 females with age of (43.2±11.3) years (range: 19 to 67 years). All the patients got the examinations of FNA and BRAF V600E mutation by Amplification Refractory Mutation System, and subsequently underwent thyroid surgeries. The results of cytopathology, frozen section and pathology were collected and analyzed. The predictive accuracy of FNA cytology and BRAF V600E mutation was calculated.
Results:In the 93 collected cases, 91 were diagnosed as papillary thyroid carcinoma postoperation, and the accurate predictive rate was 97.8%. Subgroup analysis was performed according to Bethesda System, the predictive rates were: unsatisfactory (Ⅰ) 6/6, benign (Ⅱ) 0/0, atypia of undetermined significance or follicular lesion of undetermined significance (Ⅲ) 16/17, follicular neoplasm or suspicious for follicular neoplasm (Ⅳ) 97.2% (35/36), suspicious for malignancy (Ⅴ) 100% (28/28), and malignant (Ⅵ) 6/6, respectively.
Conclusion:Thyroid nodules with BRAF V600E mutation can be strongly speculated as papillary thyroid carcinoma.
