Lung transplantation in patients with paraquat poisoning: a case report and literature review
10.3760/cma.j.issn.1001-9391.2019.04.013
- VernacularTitle: 百草枯中毒肺移植一例报告并文献复习
- Author:
Wenzhong JIANG
1
;
Yuquan CHEN
1
;
Yili ZHANG
1
;
Tingting ZHANG
1
;
Yimin LIU
1
;
Xin XU
2
Author Information
1. Guangzhou No.12 Peoples' Hospital, Guangzhou 510620, China
2. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
- Publication Type:Journal Article
- Keywords:
Paraquat;
Poisoning;
Lung transplantation
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(4):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze 8 cases of paraquat lung transplantation in the world, and to explore the timing of lung transplantation and the factors affecting prognosis.
Methods:An analysis of the clinical data of a paraquat poisoning lung transplant patient completed by The 12th People's Hospital of Guangzhou Medical University and The First People's Hospital affiliated to Guangzhou Medical University in August 2017 and literature review.
Results:A 26 years old female patient was admitted to the hospital ingested 20% paraquat solution 20ml. On the 58th day of poisoning, she underwent double lung transplantation under general anesthesia. The operation was successful. Excised lungs show extensive lung fibrosis in both lungs, which was consistent with paraquat poisoning. Used tacrolimus and corticosteroids and mycophenolate antirejection, the patient discharged 46 days after surgery. 7 articles were retrieved through the search tool, and a total of 8 articles included this case were reported. Five patients who underwent lung transplantation within 1 month after poisoning all died, And 3 patients conducted lung transplantation for more than 1 month after poisoning survived; Pathogenic bacteria were isolated from the sputum in 3 of the 8 cases, all containing Pseudomonas, 2 of which died, and our case survived.
Conclusion:Appropriate transplantation time window is very important for the prognosis of paraquat poisoning after lung transplantation. Active treatment of the sputum pathogens, improving the donor receptor matching, and exhausting the various means to remove the paraquat from the storage pool which may improve success rate of lung transplantation.
